WoS İndeksli Yayınlar Koleksiyonu

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Citation - WoS: 22
Citation - Scopus: 25
Accessibility of Vaccination Centers in COVID-19 Outbreak Control: A GIS-Based Multi-Criteria Decision Making Approach
(MDPI, 2021) Alemdar, Kadir Diler; Kaya, Omer; Codur, Muhammed Yasin; Campisi, Tiziana; Tesoriere, Giovanni
The most important protective measure in the pandemic process is a vaccine. The logistics and administration of the vaccine are as important as its production. The increasing diffusion of electronic devices containing geo-referenced information generates a large production of spatial data that are essential for risk management and impact mitigation, especially in the case of disasters and pandemics. Given that vaccines will be administered to the majority of people, it is inevitable to establish vaccination centres outside hospitals. Site selection of vaccination centres is a major challenge for the health sector in metropolitan cities due to the dense population and high number of daily cases. A poor site selection process can cause many problems for the health sector, workforce, health workers, and patients. To overcome this, a three-step solution approach is proposed: (i) determining eight criteria using from the experience of the advisory committee, (ii) calculating criterion weights using Analytic Hierarchy Process (AHP), and performing spatial analysis of criteria using Geographic Information System (GIS), (iii) assigning potential vaccination centres by obtaining a suitability map and determining service areas. A case study is performed for Bagcilar, Istanbul district, using the proposed methodology. The results show that the suitable areas are grouped in three different areas of the district. The proposed methodology provides an opportunity to execute a scientific and strategic vaccination programme and to create a map of suitable vaccination centres for the countries.
Citation - WoS: 31
Citation - Scopus: 32
Acute and Chronic Effects of Aerobic Exercise on Serum Irisin, Adropin, and Cholesterol Levels in the Winter Season: Indoor Training Versus Outdoor Training
(Wolters Kluwer Medknow Publications, 2020) Ozbay, Serhat; Ulupinar, Suleyman; Sebin, Engin; Altinkaynak, Konca
The aim of this study is to investigate the acute and chronic effects of aerobic training performed indoors and outdoors on irisin, adropin, and cholesterol levels in winter. Thirty-two healthy males participated in this study. Participants were divided into two groups: outdoor group (n = 16) and indoor group (n = 16). They then performed 40-min aerobic running exercises 4 days/week for 18 weeks. The outdoor group trained at -5 degrees C-5 degrees C environmental temperature, while the indoor group trained at 21 degrees C-25 degrees C. Blood samples were collected before and after the 18-week training period and immediately after the first training. The results showed that single aerobic exercise induced minimal increase in serum irisin concentrations in both groups. In addition, irisin levels did not change in the outdoor group but significantly decreased in the indoor group after the 18-week training period. Aerobic exercise had no acute or chronic effects on serum adropin levels in the indoor group. However, the aerobic training caused a decrease in adropin levels chronically, but there was no acute effect after single aerobic exercise in the outdoor group. Furthermore, there was no acute effect on high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and total cholesterol after single aerobic exercise in both groups. However, after the 18-week training period, there was a significant increase in HDL-C levels in both groups. Moreover, the increase in HDL-C in the outdoor group was higher than in the indoor group. Thus, this study provides evidence for the beneficial chronic effects of aerobic exercise and cold on HDL-C levels as well as the beneficial acute effects on irisin concentrations.
Citation - WoS: 7
Citation - Scopus: 7
The Acute Effects of Hip Thrust and Glute Bridge Exercises with Different Loads on Sprint Performance and Horizontal Force-Velocity Profile in Adolescent Soccer Players: A Post-Activation Performance Enhancement Approach
(Wiley, 2025) Cabuk, Salih; Ince, Izzet
This study examines the acute effects of post-activation performance enhancement (PAPE) with different loads (84% and 60% 1-RM) and exercises (hip thrust; HT and glute bridge; GB) on sprint performance (SP) and horizontal force-velocity (HF-V) profile components in adolescent male soccer players. The participants were randomly assigned to three groups: hip thrust group (HTG; n = 13), glute bridge group (GBG; n = 13), and control group (CG; n = 14). Sprint tests at distances of 10, 20, and 30 m were conducted pre-PAPE and post-PAPE protocols with a 7 min rest period. HTG and GBG executed HT and GB exercises at 84% and 60% of their 1-RM loads. Hedge's g was computed to assess within-group (pre-PAPE vs. post-PAPE) comparisons (Within-ES) and between-group (post-PAPE protocols) comparisons (Between-ES). PAPE protocols at 84% and 60% 1-RM loads demonstrated moderate effects on F0rel, Pmaxrel, FVslope, and DRF and small effects on V0, RFmax, and S20m in both HTG and GBG. Conversely, the CG exhibited trivial effects across parameters. Compared to the HTG 84% 1-RM protocol, the GBG 84% 1-RM protocol showed small effects on V0 and S10m. The HTG 60% 1-RM protocol had a small effect on RFmax compared to both GBG 84% and 60% 1-RM protocols. Both HTG and GBG 84% and 60% 1-RM protocols demonstrated small effects on S30m compared to the CG. These findings suggest that GB exercises may offer a viable alternative to HT exercises for eliciting PAPE effects, particularly in enhancing SP and related mechanics in adolescent soccer players.
Citation - WoS: 1
Citation - Scopus: 1
Acute Effects of Nordic Hamstring Exercise on Hamstring Stiffness: A Randomised Controlled Trial
(MDPI, 2025) Yagiz, Gokhan; Monleon, Cristina; Akaras, Esedullah; Adanir, Sena; Liebana, Encarnacion
Background: This study aimed to examine the immediate effects of the Nordic Hamstring Exercise (NHE) on the stiffness of the biceps femoris (BF) and semitendinosus (ST) muscles. Methods: This parallel-group randomised controlled trial followed CONSORT 2025 guidelines. Twenty-four physically active adults (16 females, 8 males) were randomly assigned to an NHE group (n = 12) or a control group (n = 12) using 1:1 gender-stratified randomisation. The NHE group performed 3 sets of 10 repetitions of the NHE, while the control group remained inactive. Muscle stiffness of the BF and ST was assessed pre- and post-intervention using the MyotonPro device. Results: No significant overall changes in hamstring stiffness were observed within or between groups (p > 0.05). Within the NHE group, the ST tended to increase in stiffness (11.25 N/m, p = 0.057), while the BF showed a small, non-significant reduction (-12.00 N/m, p = 0.696). The difference in changes between BF and ST was significant (p = 0.039). Independent of group allocation, males demonstrated significantly higher baseline stiffness than females for BF (258.13 vs. 195.81 N/m, p < 0.001) and for ST (247.88 vs. 174.00 N/m, p = 0.003). Regression analysis showed that only height predicted the change in ST stiffness after NHE (R = 0.625, R-2 = 0.39, p = 0.030). Conclusions: A single NHE session did not alter overall hamstring stiffness but produced opposite, muscle-specific effects. More research with larger, uniform samples is needed to confirm these findings.
Citation - WoS: 3
Citation - Scopus: 4
Acute Effects of Three Different Stretching Techniques on Hamstring Flexibility in Professional Football Players
(Gdansk Univ Physical Education & Sport, 2023) Erol, Erkan; Yildiz, Ramazan; Yildiz, Aye; Dogan, Fatih Emre; Elbasan, Buelent
Introduction: Hamstring injuries are common in physically active people and athletes. Lack of hamstring flexibility is the one of the most important characteristics of hamstring injuries in athletes. The aim of this study was to investigate effects of three different stretching techniques on hamstring flexibility in professional football players. Materials and Methods: Fifty-five male football players between the ages of 18-20 years old were involved in the study. The participants were divided into 3 groups: static stretching, neuromobilization and Mulligan traction straight leg raise (TSLR), respectively. Each participant's dominant lower extremity was assessed with a straight leg raise test (SLR) using a goniometer before and after the intervention. Results: There was a significant difference in the SLR range of motion before and after the intervention in all groups. There was no difference in the range of SLR between the groups at the beginning and at the end. However, the increase in the SLR range of motion was significantly higher in the Mulligan TSLR group. Conclusions: It was concluded that all 3 stretching techniques are effective in increasing hamstring flexibility in football players. However, the Mulligan TSLR technique could provide a greater increase in the range of motion than other techniques.
Citation - WoS: 1
Adaptation Levels and Expectations of Students with Disabilities in Physical Education and Sports Departments of Universities
(Ankara University, Fac Educational Sciences, 2019) Namli, Sevinc; Suveren, Sibel
This research aims to determine the adaptations and expectations of the students with disabilities, who study in the physical education and sports departments, to their deparments. The research, which is composed of explanatory sequential design out of the mixed approach designs and in which quantitative and qualitative approaches are used together, were made with the participation of all the students with disabilities studying in physical education and sports departments of 21 universities in Turkey during 2015-2016 academic year. 71 students including 27 with visual impairments, 9 with hearing impairments and 38 with physically impairments participated in the quantitative section of the research. 11 students including 4 with visually impairments, 3 with hearing impairments and 4 with physically impairments participated in the qualitative section. "Adaptation Scale of Students with Disabilities Studying in Physical Education and Sports Departments" and "Semi-structured Interview Form" were used as data collection tools. While the participants with visually impairments and physically impairments emphasized the issue of organizing the physical areas and problems in the practical lessons, the participants with hearing impairments were found to have problems in theoretical lessons. It was determined that the students with disabilities have common expectations, such as instructors sparing more time for them during the lessons.
Citation - WoS: 4
Citation - Scopus: 4
Adaptation of Symbolic Discrete Control Synthesis for Energy-Efficient Multi-Pocket Milling
(MDPI, 2024) Caska, Serkan; Ozbaltan, Mete
In engineering, cost minimization, especially in Computer Numerical Control (CNC) machining like pocket milling, is crucial. Existing tool path definition software often lacks optimization, particularly at critical starting and ending points. This study optimizes CNC machine tool paths for energy-efficient multi-pocket milling, utilizing the Symbolic Discrete Control Synthesis (SDCS) method for formal correctness. In our work, the tool path generation is formulated as a traveling salesman problem. We introduce a modeling framework to adapt SDCS to multi-pocket-milling processes, aiming to enhance precision and efficiency for potential cost savings, including energy and time, in engineering applications. This study reports experimental and comparative results, where comparative evaluations were made using metaheuristic algorithms. Our proposed approach improves CNC machining processes for multi-pocket milling. We experimentally evaluate our control algorithms and demonstrate and validate our approach through case studies.
Adherence to the Mediterranean Diet in Adults: The Role of Environmental and Sustainable Food Literacy
(BMC, 2025) Ozata-Uyar, Gizem; Aslan, Serkan; Camli, Ayse; Arslan, Merve; Bozkurt, Osman; Kocaadam-Bozkurt, Betul
AimThis study aimed to evaluate the relationship between environmental literacy, sustainable food literacy, and adherence to the Mediterranean diet (MD) in adults.MethodData were collected via a web-based questionnaire created using Google Forms between April and August 2024 in Erzurum, Turkey. A total of 394 adults participated through snowball sampling. The questionnaire included sections on demographic information, anthropometric measurements, the Environmental Literacy Scale for Adults (ELSA), the Sustainable Food Literacy Scale (SFLS), and the Mediterranean Diet Adherence Screener (MEDAS).Results38.6% of the participants were found to adhere to the Mediterranean Diet (MD). Married participants were more likely to have adhered to the MD than single ones (odds ratio [OR]:0.41, p = 0.006). Adherence to the MD was associated with higher education duration (OR = 1.05, p = 0.011), a higher SFLS total score (OR = 1.01, p = 0.025), and a higher ELSA score (OR = 1.04, p = 0.004).ConclusionThe MD is a sustainable dietary model that enhances health and is environmentally friendly. For this reason, it may be possible to direct society towards healthier and less environmentally damaging food choices through training to increase individuals' sustainable literacy and environmental literacy levels.
Citation - WoS: 2
Citation - Scopus: 2
Advanced Hybrid Modeling of Cementitious Composites Using Machine Learning and Finite Element Analysis Based on the CDP Model
(MDPI, 2025) Agcakoca, Elif; Jueyendah, Sebghatullah; Yaman, Zeynep; Sumer, Yusuf; Maali, Mahyar
This study aims to investigate the mechanical behavior of cement mortar and concrete through a hybrid approach that integrates artificial intelligence (AI) techniques with finite element modeling (FEM). Support Vector Machine (SVM) models with Radial Basis Function (RBF) and polynomial kernels, along with Multilayer Perceptron (MLP) neural networks, were employed to predict the compressive strength (Fc) and flexural strength (Fs) of cement mortar incorporating nano-silica (NS) and micro-silica (MS). The dataset comprises 89 samples characterized by six input parameters: water-to-cement ratio (W/C), sand-to-cement ratio (S/C), nano-silica-to-cement ratio (NS/C), micro-silica-to-cement ratio (MS/C), and curing age. Simultaneously, the axial compressive behavior of C20-grade concrete was numerically simulated using the Concrete Damage Plasticity (CDP) model in ABAQUS, with stress-strain responses benchmarked against the analytical models proposed by Mander, Hognestad, and Kent-Park. Due to the inherent limitations of the finite element software, it was not possible to define material models incorporating NS and MS; therefore, the simulations were conducted using the mechanical properties of conventional concrete. The SVM-RBF model demonstrated the highest predictive accuracy with RMSE values of 0.163 (R2 = 0.993) for Fs and 0.422 (R2 = 0.999) for Fc, while the Mander model showed the best agreement with experimental results among the FEM approaches. The study demonstrates that both the SVM-RBF and CDP-based modeling approaches serve as robust and complementary tools for accurately predicting the mechanical performance of cementitious composites. Furthermore, this research addresses the limitations of conventional FEM in capturing the effects of NS and MS, as well as the existing gap in integrated AI-FEM frameworks for blended cement mortars.
Citation - WoS: 62
Citation - Scopus: 70
The Advent of Indium Selenide: Synthesis, Electronic Properties, Ambient Stability and Applications
(MDPI AG, 2017) Boukhvalov, Danil W.; Gurbulak, Bekir; Duman, Songul; Wang, Lin; Politano, Antonio; Caputi, Lorenzo S.; Cupolillo, Anna
Among the various two-dimensional semiconductors, indium selenide has recently triggered the interest of scientific community, due to its band gap matching the visible region of the electromagnetic spectrum, with subsequent potential applications in optoelectronics and especially in photodetection. In this feature article, we discuss the main issues in the synthesis, the ambient stability and the application capabilities of this novel class of two-dimensional semiconductors, by evidencing open challenges and pitfalls. In particular, we evidence how the growth of single crystals with reduced amount of Se vacancies is crucial in the road map for the exploitation of indium selenide in technology through ambient-stable nanodevices with outstanding values of both mobility of charge carriers and ON/OFF ratio. The surface chemical reactivity of the InSe surface, as well as applications in the fields of broadband photodetection, flexible electronics and solar energy conversion are also discussed.
Citation - Scopus: 1
Aerobic Capacity and Respiratory Indices of Junior Cross-Country Skiers and Biathletes during Incremental Exercise Testing
(Nature Portfolio, 2024) Tortu, Erkan; Ouergui, Ibrahim; Deliceoglu, Gokhan; Keles, Ali; Ulupinar, Suleyman; Ozbay, Serhat; Ardigo, Luca Paolo
The present study compared the isocapnic buffering phase (ICB), hypocapnic hyperventilation phase, ventilatory threshold (VT), respiratory compensation point (RCP), and maximum oxygen uptake (VO2max) among biathlon and cross-country ski athletes during an incremental exercise test. 37 male and 33 female Turkish National Team athletes volunteered to participate in the research. Body fat percentage, lean mass, and fat mass values of athletes were measured using the bioelectrical impedance analysis method, and oxygen consumption (VO2) was measured with a portable cardiopulmonary exercise test system with a ramp protocol on the treadmill. In VT, RCP, and VO2max phases, male athletes had higher VO2 and speed values than female athletes (p 0.05). Additionally, XC skiers and males had higher absolute (Abs) VO2 and mass-normalized (Rel) VO2 values than biathletes and females in exhaustion times and ICBs (p 0.05). In addition, XC skiers and males had higher absolute (Abs) VO(2 )and relative (Rel) VO2 values than biathletes and females in exhaustion times and ICBs (p 0.05). These results indicate significant differences in physiological profiles between male and female athletes and between XC skiers and biathletes.
Citation - WoS: 1
Citation - Scopus: 1
Aerobic Exercise in Cold Weather May Affect Metabolic Diseases and Bone-Cartilage Formation by Increasing CTRP-3 Levels
(Wiley, 2024) Sebin, Saime Ozbek; Sebin, Engin; Gencoglu, Cebrail; Ozbay, Serhat; Ulupinar, Suleyman; Altinkaynak, Konca
Aerobic exercise is recommended by clinicians in the prevention and treatment of metabolic diseases. The aim of this study is to investigate the effect of aerobic exercise in cold weather on CTRP-3 levels and its potential implications for metabolic diseases. Twenty-seven healthy young individuals (age = 22.1 +/- 1.7 years, BMI = 22.2 +/- 1.3, and n = 27; 13 female and 14 male) voluntarily participated in this study. Participants performed 40 min aerobic running exercise at 0, 12, and 20 degrees C environmental temperatures. Our study demonstrates that 40 min of aerobic exercise at temperatures of 0 and 12 degrees C significantly increased CTRP-3 levels in athletes, while no significant change was observed at 24 degrees C. The main findings indicated significant differences between pre-and post-exercise CTRP-3 values for 0 degrees C (p = 0.001) and 12 degrees C (p = 0.005) environmental temperature, whereas no significant difference was found at 24 degrees C (p = 0.148). Additionally, two-way ANOVA revealed that both the temperature (0, 12, and 24 degrees C) and exercise (pre- and post-) affect serum CTRP-3 levels (p = 0.023). CTRP-3 elevation from baseline to post-exercise in the 0 degrees C, 12 degrees C, and 24 degrees C were +23.4%, +10.6%, and +8.1%, respectively. These findings suggest that engaging in aerobic exercise in cold weather conditions may serve as an effective intervention against metabolic disorders, including diabetes and obesity. The significant increases in CTRP-3 levels following aerobic exercise in cold weather conditions justify the need for further, more extensive studies to assess their potential impact on metabolic diseases, as well as cartilage and bone formation. Athletes' serum CTRP-3 levels in 40 min aerobic exercise at 0, 12, and 24 degrees C were evaluated by comparing them with their baselines and healthy controls' values. The significant increase in CTRP-3 levels of 0 and 120C of aerobic exercise suggests that it may influence metabolic diseases and bone-cartilage production.
Citation - WoS: 5
Citation - Scopus: 3
Alleviation of LPS-Induced Acute Lung Injury by Propolis-Based Nanocomposites Through the TLR4/NFκB and P2X7/Akt Pathways: Randomized-Controlled Experimental Study
(Pergamon-Elsevier Science Ltd, 2025) Ustundag, Hilal; Kara, Adem; Tas, Necip Gokhan; Kalindemirtas, Ferdane Danisman; Kurt, Nezahat; Erbas, Elif; Kariper, Ishak Afsin
Sepsis-associated acute lung injury continues to pose a significant medical challenge with substantial morbidity and mortality rates. In this study, we investigated the therapeutic potential of propolis-based treatments and their nanocomposites in modulating inflammation and apoptosis using a lipopolysaccharide (LPS)-induced rat model of sepsis. Forty-two Sprague-Dawley rats were divided into seven groups (n = 6): control, LPS (5 mg/kg, i. p.), LPS + Propolis (100 mg/kg, i.p.), LPS + NanoPropolis (100 mg/kg, i.p.), LPS + silver nanoparticles propolis (AgNPsPro) (50 mg/kg), and a negative propolis group (100 mg/kg, i.p.). The rats were assessed for inflammatory, oxidative stress, and apoptotic markers through Western blot, histopathological analyses, and biochemical measurements. The LPS group exhibited significantly higher levels of pro-inflammatory cytokines (IL-1 beta, TNF-alpha) and the systemic infection marker presepsin (PRSN) in blood, as well as the oxidative stress marker malondialdehyde (MDA) in lung tissue. The treatment groups, particularly LPS + AgNPsPro, showed significant reductions in these markers, with decreased levels of MDA, IL-1 beta, TNF-alpha, NF-kappa B, and TLR4, and increased GSH content in lung tissue (p < 0.05). The anti-apoptotic protein BCL-2 was upregulated, while proapoptotic BAX expression was reduced, indicating enhanced cell survival. The P2X7 receptor, a key inflammation regulator, and the AKT signaling pathway, involved in cell survival, were positively modulated by the treatments. Histopathological findings corroborated these results, showing less lung tissue damage. In conclusion, propolisbased treatments, especially in combination with nanoparticles, demonstrate therapeutic potential in reducing inflammation, oxidative stress, and apoptosis in sepsis-induced lung injury.
Citation - WoS: 4
Citation - Scopus: 7
Aluminium Phosphide-Induced Genetic and Oxidative Damages in Vitro: Attenuation by Laurus Nobilis L. Leaf Extract
(Wolters Kluwer Medknow Publications, 2013) Turkez, Hasan; Togar, Basak
Objective: The present investigation was undertaken to assess the protective effect of Laurus nobilis leaf extract (LNE) against aluminum phosphide (AIP)-induced genotoxic and oxidative damages stress in cultured human blood cells in the presence of a metabolic activator (S9 mix). Materials and Methods: Sister chromatid exchange (SCE) and chromosome aberration (CA) assays were used to assess AlP-induced genotoxicity and to establish the protective effects of LNE. In addition, we determined total antioxidant capacity (TAC) and total oxidative status (TOS) levels in AlP and LNE treated cultures for biomonitoring the oxidative alterations. Results: There was significant increases (P < 0.05) in both SCE and CA frequencies of cultures treated with AlP as compared to controls. Our results also showed that AlP (58 mg/l) caused oxidative stress by altering TAC and TOS levels. However, co-application of LNE (25, 50, 100 and 200 mg/l) and AlP resulted in decreases of SCE, CA rates and TOS level and increases of TAC level as compared to the group treated with AlP alone. Conclusion: The preventive role of LNE in alleviating AlP-induced DNA and oxidative damages was indicated for the first time in the present study.
Citation - WoS: 6
Citation - Scopus: 6
Amelino-Camelia DSR Effects on Charged Dirac Oscillators: Modulated Spinning Magnetic Vortices
(Elsevier, 2025) Guvendi, Abdullah; Mustafa, Omar; Jafari, Nosratollah
This work explores the two-dimensional Dirac oscillator (DO) within the framework of Amelino-Camelia doubly special relativity (DSR), employing a modified Dirac equation that preserves the first-order nature of the relativistic wave equation. By introducing non-minimal couplings, the system provides an exact analytical solution in terms of confluent hypergeometric functions, along with closed-form expressions for the energy spectrum (indulging a Landau-like signature along with accidental spin-degeneracies)-. In the low-energy limit, the results reproduce the well-known two-dimensional Dirac oscillator spectrum, and in the nonrelativistic regime, the results reduce the Schr & ouml;dinger oscillator spectrum. First-order corrections in this DSR model introduce a mass-splitting term proportional to +/-epsilon(degrees)/epsilon(p), where epsilon(degrees)=mc(2) is the rest energy and epsilon(p) is the Planck energy. These corrections preserve the symmetry between the energies of particles and antiparticles around zero energy, but induce a shift in the energy levels that becomes more significant for higher excited states (n>0). By mapping the system to a DSR-deformed charged Dirac oscillator in the presence of an out-of-plane uniform magnetic field, we show that the leading-order Planck-scale corrections vanish at a critical magnetic field B-0 (c), and as the magnetic field approaches this critical value, the relativistic energy levels approach E-n,E-+/- = +/-epsilon(degrees). Finally, we identify a previously undetermined feature in two-dimensional charged Dirac oscillator systems in a magnetic field, revealing that the corresponding modes manifest as spinning magnetic vortices.
Citation - WoS: 2
Citation - Scopus: 2
Amelino-Camelia Dsr Effects on Landau Levels of Dirac Pairs with Non-Minimal Coupling
(Springer, 2025) Guvendi, Abdullah; Mustafa, Omar
We present an analytical study of a fermion-antifermion (ff\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f\overline{f}$$\end{document}) system governed by a two-body Dirac equation (TBDE) in (2+1)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$(2+1)$$\end{document}-dimensional Minkowski spacetime, incorporating Dirac oscillator (DO) interactions and a uniform magnetic field. We work within Amelino-Camelia's framework, capturing leading-order Planck-scale effects while preserving the TBDE's first-order structure. Separation of center-of-mass and relative coordinates reduces the problem to a Whittaker-type radial equation, yielding a closed-form energy spectrum. DSR induces uniform energy shifts that grow with radial excitation but preserve mass symmetry between particle and antiparticle. A critical magnetic field is identified, at which Planck-scale effects vanish and the spectrum collapses to the rest mass threshold, indicating suppressed spatial resolution. These findings provide a consistent platform for probing Planckian signatures in relativistic bound states and affirm the robustness of spectral symmetries under DSR.
Citation - WoS: 22
Citation - Scopus: 22
Ameliorative Effect of Supplementation with L-Glutamine on Oxidative Stress, DNA Damage, Cell Viability and Hepatotoxicity Induced by 2,3,7,8-Tetrachlorodibenzo in Rat Hepatocyte Cultures
(Springer, 2012) Turkez, Hasan; Geyikoglu, Fatime; Yousef, Mokhtar I.; Celik, Kubra; Bakir, Tulay O.
The most potent of the dioxins, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is a persistent and ubiquitous environmental contaminant. And the health impact of exposure to TCDD is of great concern to the general public. Recent data indicate that l-glutamine (Gln) has antioxidant properties and may influence hepatotoxicity. The objective of the present study was undertaken to explore the effectiveness of Gln in alleviating the hepatotoxicity of TCDD on primary cultured rat hepatocytes. Gln (0.5, 1 and 2 mM) was added to cultures alone or simultaneously with TCDD (0.005 and 0.01 mM). The hepatocytes were treated with TCDD and Gln for 48 h. Then cell viability was detected by [3-(4,5-dimethyl-thiazol-2-yl) 2,5-diphenyltetrazolium bromide] (MTT) assay and lactate dehydrogenase (LDH) release, while total antioxidant capacity (TAC), total glutathione (TGSH) and total oxidative stress (TOS) levels were determined to evaluate the oxidative injury. The DNA damage was also analyzed by liver micronucleus assay (MN) and 8-oxo-2-deoxyguanosine (8-OH-dG). The results of MTT and LDH assays showed that TCDD decreased cell viability but not l-glutamine. TCDD also increased TOS level in rat hepatocytes and significantly decreased TAC and TGSH levels. On the basis of increasing doses, the dioxin in a dose-dependent manner caused significant increases of micronucleated hepatocytes (MNHEPs) and 8-OH-dG as compared to control culture. Whereas, in cultures exposured with Gln alone, TOS levels were not changed and TAC and TGSH together were significantly increased in dose-dependent fashion. The presence of Gln with TCDD modulated the hepatotoxic effects of TCDD on primary hepatocytes cultures. Noteworthy, Gln has a protective effect against TCDD-mediated DNA damages. As conclusion, we reported here an increased potential therapeutic significance of l-glutamine in TCDD-mediated hepatic injury for the first time.
Citation - WoS: 12
Citation - Scopus: 14
Ameliorative Effects by Hexagonal Boron Nitride Nanoparticles Against Beta Amyloid Induced Neurotoxicity
(MDPI, 2022) Aydin, Nursah; Turkez, Hasan; Tozlu, Ozlem Ozdemir; Arslan, Mehmet Enes; Yavuz, Mehmet; Sonmez, Erdal; Mardinoglu, Adil
Alzheimer's disease (AD) is considered as the most common neurodegenerative disease. Extracellular amyloid beta (A beta) deposition is a hallmark of AD. The options based on degradation and clearance of A beta are preferred as promising therapeutic strategies for AD. Interestingly, recent findings indicate that boron nanoparticles not only act as a carrier but also play key roles in mediating biological effects. In the present study, the aim was to investigate the effects of different concentrations (0-500 mg/L) of hexagonal boron nitride nanoparticles (hBN-NPs) against neurotoxicity by beta amyloid (A beta(1-42)) in differentiated human SH-SY5Y neuroblastoma cell cultures for the first time. The synthesized hBN-NPs were characterized by X-ray diffraction (XRD) measurements, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). A beta(1-42)-induced neurotoxicity and therapeutic potential by hBN-NPs were assessed on differentiated SH-SY5Y cells using MTT and LDH release assays. Levels of total antioxidant capacity (TAC) and total oxidant status (TOS), expression levels of genes associated with AD and cellular morphologies were examined. The exposure to A beta(1-42) significantly decreased the rates of viable cells which was accompanied by elevated TOS level. A beta(1-42) induced both apoptotic and necrotic cell death. A beta exposure led to significant increases in expression levels of APOE, BACE 1, EGFR, NCTSN and TNF-alpha genes and significant decreases in expression levels of ADAM 10, APH1A, BDNF, PSEN1 and PSENEN genes (p < 0.05). All the A beta(1-42)-induced neurotoxic insults were inhibited by the applications with hBN-NPs. hBN-NPs also suppressed the remarkable elevation in the signal for A beta following exposure to A beta(1-42) for 48 h. Our results indicated that hBN-NPs could significantly prevent the neurotoxic damages by A beta. Thus, hBN-NPs could be a novel and promising anti-AD agent for effective drug development, bio-nano imaging or drug delivery strategies.
Citation - WoS: 1
Ameliorative Effects of Strigolactone on Tolerance to Lead Stress on Lettuce (Lactuca Sativa L.) Plants
(Nature Portfolio, 2025) Ucar, Sumeyra; Yuce, Merve; Yigider, Esma; Aydin, Murat; Turan, Metin; Ekinci, Melek; Yildirim, Ertan
Soil contamination by heavy metals, particularly lead (Pb), which is considered the second most toxic metal, poses serious risks to plants and humans due to its accumulation from various anthropogenic activities. Strigolactones (SLs) are a novel class of terpenoid lactones that play a vital role in regulating plant growth and development, particularly under stress conditions. This study aimed to investigate the impact of exogenous SL applications on plant growth and various physiological, biochemical, and molecular parameters in lettuce subjected to Pb stress. Pb stress harmed plant growth, whereas SL treatments improved growth parameters under both control and Pb stress conditions. While Pb stress increased the electrical conductivity (EC), malondialdehyde (MDA) and hydrogen peroxide (H2O2) content, SL applications caused a decrease in these parameters. Pb stress negatively affected chlorophyll content, whereas SL applications reduced negative effect. Pb caused an increase in superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) ascorbate peroxidase (APX), glutathione reductase (GR), glutathione s-transferase (GST) activities and Glucose-6-Phosphate Dehydrogenase (G6PD), 6-Phosphogluconate Dehydrogenase (6GPD). SL treatments significantly increased the activity of antioxidant enzymes in both control and Pb stress conditions. However, Pb stressed plants had lower nitrate reductase activity (NRA) than the control plants while SL treatments increased NRA compared to the non-treatments. Pb stress significantly reduced the uptake of essential nutrients in lettuce seedlings, whereas exogenous SL applications improved nutrient accumulation, particularly under Pb-stressed conditions. Additionally, mRNA expression profiles of nine stress-related genes in different tissues of lettuce were determined. Only Pb stress significantly decreased the expression of genes, particularly LsCCD8 and LsD14, in both tissues. The combined Pb and SL treatment significantly increased the expression of LsMAX2 in both tissues. These results suggest that exogenous SL applications can be an effective strategy to mitigate Pb-induced stress in lettuce by enhancing plant tolerance at physiological, biochemical, and molecular levels.
Citation - WoS: 10
Citation - Scopus: 11
Amplification of Coupled Hot-Dry Extremes Over Eastern Monsoon China
(American Geophysical Union, 2023) Zhang, Xinxin; Gu, Xihui; Slater, Louise J.; Dembele, Moctar; Tosunoglu, Fatih; Guan, Yansong; Tang, Xiongpeng
High air temperatures and low atmospheric humidity can result in severe disasters such as flash droughts in regions characterized by high humidity (monsoon regions). However, it remains unclear whether responses of hot extremes to warming temperature are amplified on dry days as well as the response of dry extremes on hot days. Here, taking eastern monsoon China (EMC) as a typical monsoon region, we find a faster increase in air temperature on drier summer days, and a faster decrease in atmospheric humidity on hotter days, indicating "hotter days get drier" and "drier days get hotter" (i.e., coupling hotter and drier extremes), especially in southern EMC. The southern EMC is also a hotspot where the coupling hot-dry extremes has become significantly stronger during the past six decades. The stronger hot-dry coupling in southern EMC is associated with anomalies in large-scale circulations, such as reduced total cloud cover, abnormal anticyclones in the upper atmosphere, intense descending motion, and strong moisture divergence over this region. Land-atmosphere feedback enhance the hot-dry coupling in southern EMC by increasing land surface dryness (seen as a decrease in the evaporation fraction). The decreasing evaporation fraction is associated with drying surface soil moisture, controlled by decreases in pre-summer 1-m soil moisture and summer-mean precipitation. Given hot extremes are projected to increase and atmospheric humidity is predicted to decrease in the future, it is very likely that increasing hot-dry days and associated disasters will be witnessed in monsoon regions, which should be mitigated against by adopting adaptive measures. High air temperatures (i.e., hot extremes) and low atmospheric humidity (i.e., dry extremes) are regarded as important metrics affecting human society and the environment in monsoon regions, including food production and natural disasters. Our results show that over eastern monsoon China (EMC), positive responses of hot extremes to warming temperature are magnified on dry days, at the same time, negative responses of dry extremes to warming temperature are enhanced on hot days. In other words, the warming rates of hot extremes per 1 degrees C warming are fastest on dries days, meanwhile, the drying rates of dry extremes per 1 degrees C warming are fastest on hottest days, especially in southern EMC. The southern EMC is also a hotspot where more hot or dry days have become hot-dry days (i.e., stronger coupling of hot and dry extremes) during the past six decades. This stronger coupling of hot and dry extremes can be explained by anomalous large-scale circulations and land-atmosphere feedbacks in southern EMC. Our findings suggest that the positive coupling of hotter and drier extremes should be taken into consideration, and adaptive measures are required to mitigate adverse effects of hot and dry extremes. Positive (negative) responses of hot (dry) extremes to warming temperature are amplified on dry (hot) days over eastern monsoon ChinaCoupling of hot and dry extremes has strengthened in past six decades in southern EMCCoupling of hotter and drier extremes can be explained by anomalies of large-scale circulations and land-atmosphere feedbacks

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