Browsing by Author "Akbari, Ali"

Now showing 1 - 2 of 2

Cytotoxicity and Antibacterial Activity of Polyhedral Oligomeric Silsesquioxane Modified Ti3C2Tx MXene Films
(Nature Portfolio, 2025) Akinay, Yuksel; Karatas, Erkan; Ruzgar, Damla; Akbari, Ali; Baskin, Dilges; Cetin, Tayfun; Topuz, Mehmet
Bioactive antimicrobial films play important roles in various fields, such as biodegradable interfaces, tissue regeneration, and biomedical applications where preventing infection, biocompatibility, and immune rejection are important. In the present study, bioactive POSS-doped Ti3C2Tx MXene filled PLA composite film was prepared using the solution casting method for biomedical applications. The contact angle tests were investigated to reveal the usability of the thin films in biomedical applications. The angle decreased from 85.92 degrees degrees in pure PLA thin films to 72.23 degrees on POSS-doped Ti3C2Tx MXene films. The antibacterial performance, cytotoxicity and cell viability assessments of the prepared films have also been thoroughly investigated. Antibacterial tests revealed that the POSS-doped Ti3C2Tx MXene films effectively inhibited the growth of E. coli and S. aureus by 65.93% and 80.63%, respectively, within 4 h. These inhibition rates were observed as 58.32% and 54.97% for E. coli and S. aureus, respectively, after 24 h. Cytotoxicity assessments demonstrated that PMPs consistently showed higher cell viability due to the combination of POSS and Ti3C2Tx MXene. The obtained results suggest that the POSS-doped Ti3C2Tx MXene film is a promising candidate in cases where bacterial inhibition and high biocompatibility are of critical importance.
Functionalized Exosomes for Targeted Therapy in Cancer and Regenerative Medicine: Genetic, Chemical, and Physical Modifications
(BMC, 2025) Gabaran, Salar Ghaffari; Ghasemzadeh, Navid; Rahnama, Maryam; Karatas, Erkan; Akbari, Ali; Rezaie, Jafar
BackgroundExtracellular vesicles (EVs), such as exosomes, have been extensively discovered for their function in various diseases and potential therapeutic properties. In this review, we aimed to describe the therapeutic roles of functionalized exosomes in cancer and regenerative medicine.MethodsIn this review study, we studied numerous articles over the past two decades published on the application of exosomes in different diseases, as well as on perspectives and challenges in this field.ResultsRecent advancements have shown that exosomes can be used as a drug delivery system. However, this approach faces challenges such as low efficiency and non-targeting effects. Different methods, including genetic, chemical, and physical modifications, are used to functionalize exosome surfaces to address these limitations. In some cases, a combination of modification methods has been used to produce smart exosomes. Different therapeutic agents have been inserted on exosome surfaces by different modification methods. These functionalized exosomes can effectively deliver therapeutic agents to target cells. A growing body of evidence shows that functionalized exosomes are promising for cancer therapy and regenerative medicine. They can not only effectively deliver therapeutic agents to cancer cells, inhibiting tumorigenesis, but also efficiently contribute to tissue repair and regeneration by increasing cell proliferation and angiogenesis. In this review, we discuss different modification methods used to functionalize exosomes and related studies. In addition, we describe the application of functionalized exosomes in cancer and regeneration, along with challenges and perspectives.ConclusionsAlthough functionalized exosomes show promising results, further studies are essential for the clinical translation of these exosomes.