Browsing by Author "Altinkaynak, Konca"

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Acute and Chronic Effects of Aerobic Exercise on Serum Irisin, Adropin, and Cholesterol Levels in the Winter Season: Indoor Training Versus Outdoor Training
(Wolters Kluwer Medknow Publications, 2020) Ozbay, Serhat; Ulupinar, Suleyman; Sebin, Engin; Altinkaynak, Konca
The aim of this study is to investigate the acute and chronic effects of aerobic training performed indoors and outdoors on irisin, adropin, and cholesterol levels in winter. Thirty-two healthy males participated in this study. Participants were divided into two groups: outdoor group (n = 16) and indoor group (n = 16). They then performed 40-min aerobic running exercises 4 days/week for 18 weeks. The outdoor group trained at -5 degrees C-5 degrees C environmental temperature, while the indoor group trained at 21 degrees C-25 degrees C. Blood samples were collected before and after the 18-week training period and immediately after the first training. The results showed that single aerobic exercise induced minimal increase in serum irisin concentrations in both groups. In addition, irisin levels did not change in the outdoor group but significantly decreased in the indoor group after the 18-week training period. Aerobic exercise had no acute or chronic effects on serum adropin levels in the indoor group. However, the aerobic training caused a decrease in adropin levels chronically, but there was no acute effect after single aerobic exercise in the outdoor group. Furthermore, there was no acute effect on high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and total cholesterol after single aerobic exercise in both groups. However, after the 18-week training period, there was a significant increase in HDL-C levels in both groups. Moreover, the increase in HDL-C in the outdoor group was higher than in the indoor group. Thus, this study provides evidence for the beneficial chronic effects of aerobic exercise and cold on HDL-C levels as well as the beneficial acute effects on irisin concentrations.
Aerobic Exercise in Cold Weather May Affect Metabolic Diseases and Bone-Cartilage Formation by Increasing CTRP-3 Levels
(Wiley, 2024) Sebin, Saime Ozbek; Sebin, Engin; Gencoglu, Cebrail; Ozbay, Serhat; Ulupinar, Suleyman; Altinkaynak, Konca
Aerobic exercise is recommended by clinicians in the prevention and treatment of metabolic diseases. The aim of this study is to investigate the effect of aerobic exercise in cold weather on CTRP-3 levels and its potential implications for metabolic diseases. Twenty-seven healthy young individuals (age = 22.1 +/- 1.7 years, BMI = 22.2 +/- 1.3, and n = 27; 13 female and 14 male) voluntarily participated in this study. Participants performed 40 min aerobic running exercise at 0, 12, and 20 degrees C environmental temperatures. Our study demonstrates that 40 min of aerobic exercise at temperatures of 0 and 12 degrees C significantly increased CTRP-3 levels in athletes, while no significant change was observed at 24 degrees C. The main findings indicated significant differences between pre-and post-exercise CTRP-3 values for 0 degrees C (p = 0.001) and 12 degrees C (p = 0.005) environmental temperature, whereas no significant difference was found at 24 degrees C (p = 0.148). Additionally, two-way ANOVA revealed that both the temperature (0, 12, and 24 degrees C) and exercise (pre- and post-) affect serum CTRP-3 levels (p = 0.023). CTRP-3 elevation from baseline to post-exercise in the 0 degrees C, 12 degrees C, and 24 degrees C were +23.4%, +10.6%, and +8.1%, respectively. These findings suggest that engaging in aerobic exercise in cold weather conditions may serve as an effective intervention against metabolic disorders, including diabetes and obesity. The significant increases in CTRP-3 levels following aerobic exercise in cold weather conditions justify the need for further, more extensive studies to assess their potential impact on metabolic diseases, as well as cartilage and bone formation. Athletes' serum CTRP-3 levels in 40 min aerobic exercise at 0, 12, and 24 degrees C were evaluated by comparing them with their baselines and healthy controls' values. The significant increase in CTRP-3 levels of 0 and 120C of aerobic exercise suggests that it may influence metabolic diseases and bone-cartilage production.
Effect of Origanum Dubium, Origanum Vulgare Subsp. Hirtum, and Lavandula Angustifolia Essential Oils on Lipid Profiles and Liver Biomarkers in Athletes
(Walter de Gruyter Gmbh, 2022) Maral, Hasan; Ulupinar, Suleyman; Baydir, Aysegul Turk; Ozbay, Serhat; Altinkaynak, Konca; Sebin, Engin; Ince, Izzet
This study aims to determine the effects of essential oils of Origanum dubium (DUB), Origanum vulgare subsp. hirtum (HIR), and Lavandula angustifolia (LAV) on lipid profiles and liver biomarkers in athletes. Thirty-four trained athletes were randomly assigned to one of three experimental groups or the control group (CON). The concentrations of serum lipids and liver biomarkers were assessed before and after the 14-day essential oil intervention. Gas chromatography-mass spectrometry analysis showed 68.0 and 82.1% carvacrol in DUB and HIR, respectively, and 34.50% linalyl acetate and 33.68% linalool in LAV essential oils. One-way analysis of covariance (ANCOVA) indicated a significant difference (p = 0.001) among the groups for high-density lipoprotein cholesterol (HDL-C) when the associated preintervention values were used as a covariate. The related pairwise comparisons revealed that DUB (p = 0.001) and HIR (p = 0.024) had greater HDL-C values than CON. From the two-way ANOVA, an interaction between time (before vs. after) and the groups (DUB vs. HIR vs. LAV vs. CON) was found for HDL-C (p = 0.030). Findings indicated a significant increase in DUB (p = 0.0001) and HIR (p = 0.010) for HDL-C, and there was a significant decrease in DUB (p = 0.023) for low-density lipoprotein cholesterol. However, there was no difference in total cholesterol, triglycerides, and all liver biomarkers.
Exercise in the Cold Causes Greater Irisin Release but May Not Be Enough for Adropin
(Wolters Kluwer Medknow Publications, 2021) Ulupinar, Suleyman; Ozbay, Serhat; Gencoglu, Cebrail; Altinkaynak, Konca; Sebin, Engin; Oymak, Burak
When irisin and adropin were discovered, it was popularly hoped that they would become therapies for metabolic disorders that threaten global health. However, contradictory results have been reported in the subsequent period. Irisin, induced by exercise or cold exposure, is believed to be a myokine that causes the browning of adipose tissue thus increasing energy expenditure. Adropin is thought to be beneficial for health by regulating blood flow, capillary density, and playing an active role in glucose and insulin homeostasis. However, there were no experimental studies investigating the simultaneous effect of exercise and cold exposure in humans. The purpose of this study was to investigate irisin and adropin responses in young healthy individuals performing aerobic exercise in different environmental temperatures. Twenty-seven young, healthy individuals participated in this study. Participants performed 40 min of aerobic running exercise in environmental temperatures of 0 degrees C, 12 degrees C, and 24 degrees C. Venous blood samples were taken pre- and post-exercise. Irisin and adropin levels were analyzed using an enzyme-linked immunosorbent assay. The principal findings showed that while serum irisin concentrations significantly increased after aerobic exercise was performed at an environmental temperature of 0 degrees C, there was no significant difference between pre- and post-exercise recordings for physical activity performed at 12 degrees C and 24 degrees C. Adropin concentrations, however, remained unchanged between pre- and post-exercise at 0 degrees C, 12 degrees C, and 24 degrees C. Interestingly, the exercise at 0 degrees C caused an increase in adropin (12.5%), but this amount was not enough to be a statistically significant result. The findings of this study suggest that aerobic exercise in a cold environment causes greater irisin release. However, the combined effect of exercise and cold exposure may not be enough to statistically increase adropin level.
Farklı Hava Sıcaklıklarında Yapılan Aerobik Egzersizlerin Bağışıklık Hücrelerine Akut Etkisi
(2021) Şebin, Engin; Özbay, Serhat; Ulupınar, Süleyman; Gençoğlu, Cebrail; Altinkaynak, Konca
ÖZET Amaç: Egzersizin bağışıklık sistemi üzerine olan etkileri uzun yıllardır sıkça araştırılan bir konudur. Ancak farklı şiddetlerde yapılan egzersizlerin bağışıklık sistemi üzerine olan etkileri büyük ölçüde bilinirken, farklı hava sıcaklıklarında uygulan egzersizlerin etkileri hakkında sınırlı sayıda çalışma vardır. Bu çalışmanın amacı, farklı hava sıcaklıklarında yapılan aerobik egzersizin bağışıklık hücrelerine olan etkilerini araştırmaktır. Gereç ve Yöntemler: Araştırmaya 27 sağlıklı genç birey gönüllü olarak katılmıştır. Katılımcılara 3 farklı sıcaklıkta (0,12 ve 24 °C) 40 dk’lık aerobik koşu egzersizi uygulanmıştır. Koşu hızı, katılımcıların maksimum kalp atım hızlarının %65-70’ine (%50- 55 VO2maks) karşılık gelen aralıkta tutulmuştur. Katılımcılardan, egzersizlerin öncesinde ve sonrasında kan örnekleri alınmıştır. Katılımcıların bağışıklık fonksiyonları için lökosit ve alt grupları (lenfosit, monosit ve granülosit) kan sayımı ile venöz kan örneklerinden belirlenmiştir. Elde edilen verilerin istatistiksel analizleri eşli örneklem t-testi (önce-sonra) ile yapılmıştır. Bulgular: Yapılan araştırma sonucunda 0°C ve 12°C sıcaklıklarda yapılan egzersizlerde lökosit (sırasıyla p=0,015 ve p=0,006) ve nötrofil sayıları (sırasıyla p=0,018 ve p=0,021) önemli derecede artarken, 24°C sıcaklıkta ise sadece nötrofil sayılarında (p=0,046) artış görülmüştür. Diğer kan hücrelerinde 3 farklı sıcaklıkta yapılan egzersizlerde de herhangi bir değişime rastlanmamıştır (p>0,05). Sonuç: Sonuç olarak bu çalışma, çevre sıcaklığı değiştikçe aerobik egzersizlere farklı bağışıklık tepkilerinin oluşabileceğini ortaya koymaktadır.
Low Vitamin D and High Cholesterol Facilitate Oral Carcinogenesis in 4NQO-Induced Rat Models Via Regulating Glycolysis
(Wiley, 2023) Gumus, Rasim; Capik, Ozel; Gundogdu, Betul; Tatar, Arzu; Altinkaynak, Konca; Tozlu, Ozlem Ozdemir; Karatas, Omer Faruk
Objectives Diets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal origin facilitates carcinogenesis. In this study, we aimed at investigating the possible involvement of vitamin D deficiency (VDD) and high cholesterol (HC) together in oral squamous cell carcinoma (OSCC) through modulating glycolysis. Subjects and Methods We compared total cholesterol, LDL, HDL, triglycerides, LDH, and vitamin D levels of OSCC patients and control individuals. We used GEO datasets for gene set enrichment and 4-nitroquinoline-1-oxide induced in vivo oral carcinogenesis models to investigate contribution of VDD and HC during carcinogenesis via possible modulation of glycolysis. Results We found that VDD and HC co-exist in OSCC patients, and deregulation of cholesterol and vitamin D levels results in enrichment of genes related to glycolysis. We, then, demonstrated that VDD and HC on their own and together facilitated the formation of larger tumors in 4NQO-induced in vivo cancer models, which are suppressed by glycolysis inhibition. Conclusion We reported collaborative contribution of HC and VDD during oral carcinogenesis, which is mainly carried out via altering energy metabolism in tumor cells.