Bilgilendirme: Kurulum ve veri kapsamındaki çalışmalar devam etmektedir. Göstereceğiniz anlayış için teşekkür ederiz.

Browsing by Author "Celebioglu, Neslihan"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Article
    Synthesis of Alnustone-Like Diarylpentanoids Via a 4+1 Strategy and Assessment of Their Potential Anticancer Activity
    (TÜBİTAK Scientific & Technological Research Council Turkey, 2023) Celebioglu, Neslihan; Ozdemir Tozlu, Ozlem; Turkez, Hasan; Secen, Hasan
    Twelve compounds with a 1,5-diaryl-1-penten-3-one structure were synthesized and their cytotoxic activities were evaluated. The 1,5-diaryl-1-penten-3-one compounds were obtained via in situ enaminations of 4-phenyl-2-butanone and 4-(4-hydroxyphenyl)-2butanone in the presence of pyrrolidine-AcOH, followed by condensation with six different benzaldehydes. The synthesized compounds were tested for their cytotoxic activity against human glioblastoma (U87-MG), breast (MCF-7), and prostate (PC-3) cancer cell lines. Some of the novel compounds exhibited remarkable cytotoxic action, especially against MCF-7 cancer cells.