Browsing by Author "Eyipinar, Cemre Didem"

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Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? a Double-Blind, Placebo-Controlled Study
(MDPI, 2022) Ozan, Murat; Buzdagli, Yusuf; Eyipinar, Cemre Didem; Baygutalp, Nurcan Kilic; Yuce, Neslihan; Oget, Furkan; Baygutalp, Fatih
In previous studies, the effect of single or combined intake of caffeine (CAF) and taurine (TAU) on exercise performance was investigated. However, the potential synergistic effect on physical and cognitive performance after fatigue induced by anaerobic exercise is unknown. The effects of single and combination CAF and TAU supplementation on the Wingate test in elite male boxers and to evaluate balance, agility and cognitive performance after fatigue are being investigated for the first time in this study. Twenty elite male boxers 22.14 +/- 1.42 years old were divided into four groups in this double-blind, randomized crossover study: CAF (6 mg/kg of caffeine), TAU (3 g single dose of taurine), CAF*TAU (co-ingestion of 3 g single dose of taurine and 6 mg/kg of caffeine) and PLA (300 mg maltodextrin). The findings are as follows: co-ingestion of CAF*TAU, improved peak (W/kg), average (W), minimum (W) power, time to reach (s), and RPE performances compared to the PLA group significantly (p < 0.05). Similarly, it was determined that a single dose of TAU, created a significant difference (p < 0.05) in peak power (W/kg), and average and minimum power (W) values compared to the CAF group. According to the balance and agility tests performed after the Wingate test, co-ingestion of CAF*TAU revealed a significant difference (p < 0.05) compared to the PLA group. In terms of cognitive performance, co-ingestion of CAF*TAU significantly improved the neutral reaction time (ms) compared to the TAU, CAF and PLA groups. As a result, elite male boxers performed better in terms of agility, balance and cognitive function when they consumed a combination of 6 mg/kg CAF and 3 g TAU. It has been determined that the combined use of these supplements is more effective than their single use.
Effect of Taurine Supplement on Aerobic and Anaerobic Outcomes: Meta-Analysis of Randomized Controlled Trials
(Lippincott Williams & Wilkins, 2023) Buzdagli, Yusuf; Eyipinar, Cemre Didem; Tekin, Aslihan; Siktar, Erdinc; Zydecka, Karolina Skonieczna
Taurine is a well-known free amino acid that has gained prominence in recent years despite its little or no role in protein formation. Few studies on the ergogenic effect of taurine exist with inconsistent results. This study aimed to reach a consensus about whether taurine supplementation is effective on aerobic and anaerobic performance outputs. Google Scholar, Pubmed databases, clinical trial websites, and grey literature were reviewed until November 2021. Mean differences were pooled using random or fixed-effects models according to the heterogeneity degree of related outcomes. Although 17 studies were detected for the meta-analysis between 2001-2021, 15 studies were grouped. Only randomized controlled trials were considered. Taurine supplementation had a significant effect on vertical (MD = 3.60; 95% CI [2.32 to 4.89], p < 0.00001) and countermovement (MD = 8.50; 95% CI [4.78 to 12.22], p < 0.00001) jump performance when compared to a placebo group. Taurine supplementation had no significant effect on V?o(2)max level and rate of perceived exertion (respectively, MD = -0.54 mL/kg/min; 95% CI [-6.84 to 5.75], p = 0.87; MD = -0.24; 95% CI [-0.74 to 0.27], p = 0.35) when compared to a placebo group. Taurine improves potentially jumping performance and time to exhaustion.
Effects of Hesperidin on Anti-Inflammatory and Antioxidant Response in Healthy People: A Meta-Analysis and Meta-Regression
(Taylor & Francis Ltd, 2023) Buzdagli, Yusuf; Eyipinar, Cemre Didem; Kaci, Fatma Necmiye; Tekin, Aslihan
Hesperidin is a prominent flavanone found in citrus fruits that has a broad range of biological effects, including anti-inflammatory and antioxidant capabilities. The study's objective was to evaluate the effects of hesperidin supplementation on anti-inflammatory and antioxidant parameters such as MDA, TAC, GSH, SOD, and CAT; CRP, TNF-alpha, IL-6, and IL-4 levels respectively, by analyzing human intervention trials. Google Scholar, PubMed, grey literature databases, and the ClinicalTrials website were scanned to identify eligible studies. For the meta-analysis, eighteen studies were chosen. Hesperidin supplementation had significant lowering effect on not only CRP, IL-6, and IL-4 levels but also MDA level (Meta-regression analysis revealed a non-significant direct relationship between hesperidin dosage and chance in CRP, IL-6, and MDA levels. As a result, it can be said that hesperidin supplementation contributes to the inflammatory and antioxidant response, but this contribution is independent of dosage.
Hypertrophic Response of Lower Extremity Muscles to Different Resistance Training Intensities: A Meta-Analysis and Meta-Regression
(Univ Ljubljana Press, 2025) Eyipinar, Cemre Didem; Buzdagli, Yusuf; Karayigit, Raci
This research aims to detect the effectiveness of different resistance training intensities (high, moderate, and low) for quadriceps femoris muscle group hypertrophic response in healthy adults. The literature search was conducted during January 2023 using the Web of Science, SPORTDiscus, Embase, PubMed, Google Scholar, ClinicalTrials website, and grey literature databases. Using the TESTEX scale, we assessed the studies' methodological quality. This meta-analysis was comprised of 22 studies (with 519 participants). Statistical analysis was performed using ReviewManager 5.2 (RevMan) software. This analysis showed potential benefits for all resistance training intensities on quadriceps femoris muscle group hypertrophy (muscle thickness (mm) for quadriceps muscle) compared with control (or pre-test values) groups. The data obtained are as follows, high-intensity resistance training: [Raw mean difference (RMD)= [2.3; confidence interval (CI) 95%: [2.21-2.38]]; Moderate-intensity (60-79% of 1RM) resistance training: [RMD = 1.88; (CI) 95%: [1.74- 2.02]] and low-intensity (30-59 % of 1 RM) resistance training: [RMD = 10.92; CI 95%: [10.77- 11.08]] with p<0.00001. Meta-regression analysis revealed that the non-significant direct relationship between resistance training intensity (%) and change in RF (mm) (beta=0.03; p = 0.417; R-2 = 0.04) and VM muscle thickness (beta = 0.003; p = 0.895; R-2 = 0.002). In addition, a significant direct relationship between resistance training intensity and change in VI (beta=0.01; p = 0.05; R-2 = 0.56) and VL muscle thickness (beta = 0.01; p = 0.007; R-2 = 0.34) was detected. In conclusion, studies employing different resistance training intensities showed similar hypertrophic responses in all muscles. The meta-regression analysis found that for every 10% greater difference in resistance exercise intensity between studies, the hypertrophic response in the VI muscle was determined to be 0.1 mm greater. No significant hypertrophic response was observed for VL, VM, and RF muscles.
Taurine Supplementation Enhances Anaerobic Power in Elite Speed Skaters: A Double-Blind, Randomized, Placebo-Controlled, Crossover Study
(Termedia Publishing House Ltd, 2023) Buzdagli, Yusuf; Eyipinar, Cemre Didem; Oget, Furkan; Siktar, Erdinc; Forbes, Scott C.; Tekin, Aslihan
Taurine (2-aminoethanesulfonic acid) is a semi-essential sulphur-containing amino acid abundant in skeletal muscle. Taurine supplementation is popular among athletes and has been purported to enhance exercise performance. This study aimed to investigate the ergogenic effects of taurine supplementation on anaerobic (Wingate; WanT) performance, blood lactate, ratings of perceived exertion (RPE), and countermovement vertical jump (CMJ) in elite athletes. For this study, randomized, double-blind, placebo-controlled crossover designs were used. Thirty young male speed skaters were randomly assigned to either taurine (TAU; single dose of 6 g) or placebo (PLAC; single dose of 6 g) 60 minutes before testing. Following a 72-hour washout, period participants completed the opposite condition. TAU improved peak (A% = 13.41, p < 0.001, d = 1.71), mean (A% = 3.95, p = 0.002, d = 1.04), and minimum power output (A% = 7.89, p = 0.034, d = 0.48) compared to placebo. Further, RPE (A% =-10.98, p = 0.002, d = 0.46) was significantly lower following the WanT in the TAU condition compared to placebo. There were no differences between conditions for the countermovement vertical jump. In conclusion, acute TAU supplementation augments anaerobic performance in elite speed skaters.