Browsing by Author "Gulluoglu, Sukru"

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Overexpression of miR145 Inhibits Proliferation of Prostate Cancer Cells and Reduces Sox2 Expression
(Taylor & Francis Inc, 2015) Ozen, Mustafa; Karatas, Omer Faruk; Gulluoglu, Sukru; Bayrak, Omer Faruk; Sevli, Serhat; Guzel, Esra; Ittmann, Michael
We aimed to perform functional analysis of miR-145-5p in prostate cancer (PCa) cells and to identify targets of miR-145-5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic prostate cell lines were utilized for functional analysis of miR-145-5p. Its overexpression caused inhibition of proliferation through apoptosis and reduced migration in PCa cells. SOX2 expression was significantly decreased in both mRNA and protein level in miR-145-5p-overexpressed PCa cells. We proposed that miR-145-5p, being an important regulator of SOX2, carries a crucial role in PCa tumorigenesis.