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Browsing by Author "Koca, Mehmet"

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    A Caryophyllene Oxide and Other Potential Anticholinesterase and Anticancer Agent in Salvia Verticillatasubsp. Amasiaca (Freyn & Bornm.) Bornm. (Lamiaceae)
    (Taylor & Francis Inc, 2020) Karakaya, Songul; Yilmaz, Serdar Volkan; Ozdemir, Ozlem; Koca, Mehmet; Pinar, Nur Munevver; Demirci, Betul; Baser, K. Husnu Can
    In vitro cholinesterase inhibition, antioxidant and anticancer potentials of the essential oils and extracts of flowers and aerial parts of Salvia verticillata subsp. amasiaca have been studied. The GC-MS and GC-FID analyses found that major components of the essential oils were caryophyllene oxide, caryophylladienol II, spathulenol, hexahydrofarnesyl acetone and phytol. Oxygenated sesquiterpenes and sesquiterpene hydrocarbons were identified in the essential oils as the dominating groups of compounds. Caryophyllene oxide indicated strong cholinesterase inhibitory activities and antioxidant effect. The essential oil from aerial parts exhibited high anticancer activity on U-87 MG and PC-3 cells with 0% and 45.56% cell viability, respectively. Microscopic analysis of different parts of the experimental plant revealed that glandular trichomes of flowers contain more oxygenated sesquiterpene hydrocarbons, while glandular trichomes of the aerial parts contain monoterpene hydrocarbons. It was confirmed that S. verticillata subsp. amasiaca had similar kinds of capitate and peltate trichomes like other Salvia members.
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    Cytotoxic Effect and Molecular Docking Studies of Essential Oils Ofcymbocarpum Erythraeum (Dc.) Boiss. (Apiaceae) as Potential Inhibitors of Cholinesterase
    (Taylor & Francis Inc, 2020) Karakaya, Songul; Ozdemir, Ozlem; Koca, Mehmet; Demirci, Betul; Aksakal, Ozkan; Turkez, Hasan; Baser, K. Husnu Can
    This investigation displays antioxidant potential ofCymbocarpum erythraeumessential oils and their biological effects like cytotoxic and anticholinesterase. The antioxidant capacities of the essential oils were estimated by DPPH, TBA, TOS assays. The anticholinesterase activity of essential oils was estimated utilizing Ellman method. The human U-87MG and PC-3 were handled and measurements were estimated by MTT test. The root essential oil showed high cytotoxic activity on PC-3 cells with 48.33% whereas aerial part essential oils indicated high cytotoxic activity on U-87MG cells with 34.62% at 0.03 mg/L. Root oil presented the highest acetylcholinesterase and butyrylcholinesterase inhibition (IC50: 113, 197 mu M, respectively). The GC-FID and GC-MS assays showed that major components of aerial part with flowers and root oils were (E)-2-decenal (52.1%); (E)-2-dodecenal (36.1%), and (E)-2-tetradecenal (22.3%), respectively. (E)-2-dodecenal was a major compound of root il and exhibited AChE and BuChE inhibitory (IC50: 100, 136 mu M, respectively) and antioxidant effects.