Browsing by Author "Ozgeris, B."

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Analysis of Biological Activity of Sulfamide Derivatives as Antimicrobial Agents
(AMG Transcend Association, 2023) Yildirim, M.; Ruzgar, D.; Ozgeris, B.; Gormez, A.
Sulfamides are significant compounds because of their biological effects on bacteria, fungi, and cancer. The antimicrobial and anticancer properties of sulfamide derivatives have been demonstrated in several microbial strains and cancer cell lines. They have worked mostly in the field of medicinal chemistry. Numerous microbiological pathogens are known to be resistant to the antibacterial effects of sulfamide derivatives. The most significant microorganisms in command of hospital-acquired nosocomial infections include Acinetobacter baumannii (A. baumannii), Methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans (C. albicans), and Candida parapsilosis (C. parapsilosis). Multiple antibiotics can no longer treat these illnesses. Therefore, it is crucial to develop new antimicrobial agents. Three previously made compounds were tested for their antibacterial properties against these pathogens, including 3-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethyl sulfamide (4) and 3-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethyl sulfamide (5). Using the disc diffusion method, antimicrobial activity was assessed, and values for the minimum inhibitory concentration (MIC) were calculated for zone formation seen in the tested pathogens. The results of the investigation demonstrated that sulfamide derivatives stopped the growth of bacteria against A. baumannii with zone widths of 7-9 mm, but had no impact on MRSA, C. albicans, and C. parapsilosis. Sulfamide derivatives' MIC values against A. baumannii were discovered to be 3.90 g/ml. These results provide us the ability to evaluate these sulfamide derivatives as potential new antibacterial therapies for A. baumannii. © 2022 by the authors.
Synthesis and Characterization of New N-Substituted 2- Aminopyrrole Derivatives
(ACG Publications Emlak Bankasi Mutlukent Konutlari, Okyanus 3 D:4 Gebze-Kocaeli, 2019) Aksu, K.; Ozgeris, B.; Tümer, F.
In this work, new N-substituted 2-aminopyrrole derivatives were synthesized. Initially, some crotonitriles were prepared by condensation of malononitrile with arylmethylketones, which was followed by conversion of them to the bromocrotonitriles. Finally, the synthesis of new N-substituted 2-aminopyrrole derivates were successfully achieved by cyclization of the bromocrotonitriles of (R)-1-phenylethylamine applying Gewald method. © 2019 ACG Publications.
Synthesis of Substituted Phenethylamine-Based Thioureas and Their Antimicrobial and Antioxidant Properties
(Pleiades Publishing Ltd, 2021) Ozgeris, B.
Thiourea-based scaffolds are increasingly used in medicinal chemistry owing to their tunable structural properties. This study demonstrates the first examples of phenethylamine-based thiourea derivatives and their antimicrobial and antioxidant activities. All compounds exhibited strong antibacterial activity against tested bacteria known to cause nosocomial infections, which have acquired resistance to many antibiotics, and also strong antioxidant properties. Therefore, they can be evaluated as possible antibacterial and antioxidant agents in the treatment of bacterial infections and many health problems related to aging.