Browsing by Author "Yuca, Hafize"

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Integrative Study of Plantago Lanceolata L.: Phytochemical Properties and Therapeutic Effects on Cancer, Diabetes, and Alzheimer's Disease
(Taylor & Francis Ltd, 2025) Kadi, Abdulrahim; Oner, Sena; Yuca, Hafize; Arslan, Mehmet Enes; Atila, Alptug; Incekara, Umit; Karakaya, Songul
Alzheimer's disease is linked with diabetes and cancer, emphasising the need for effective treatments. Plantago lanceolata, recognised as safe by various pharmacopeias, was investigated in this study for therapeutic potential. We examined the effects of its leaf extracts and sub-extracts (methanol, hexane, dichloromethane, ethyl acetate, butanol, aqueous) on AChE, BChE, alpha-amylase, alpha-glucosidase enzymes, as well as their impact on HDF-a and U87-MG cancer cells. The phytochemical characterisation was performed using ICP-MS and LC-MS/MS. Cytotoxic effects were evaluated on HDF-a and U87-MG cell lines, along with assessments for nuclear abnormalities. Na and K were detected in extracts, with isoleucine and cyanidin-3-O-glucoside being the most concentrated compounds. Extracts at concentrations exceeding 25 mu g/mL significantly increased cytotoxicity in HDF-a cell lines compared to the control group, without inducing nuclear abnormalities. Methanol extract demonstrated moderate inhibition against AChE and BChE at concentrations of 100 mu g/mL and 500 mu g/mL, respectively. These findings suggest that extracts exhibit potential therapeutic effects.
Phytochemical Analysis and Biological Evaluation of Essential Oils and Extracts from Heracleum Pastinacifolium Subsp. Incanum (Boiss. & A.Huet) Phdavis, an Endemic Plant from Turkey
(Taylor & Francis Ltd, 2025) Yuca, Hafize; Sefali, Abdurrahman; Aydin, Bilge; Karadayi, Mehmet; Gulsahin, Yusuf; Yazici, Aysenur; Guvenalp, Zuhal
Essential oil content of and phenolic compounds flower-fruit, root, and aerial parts of Heracleum pastinacifolium subsp. incanum were analysed by GC/MS and LC/MS methods, respectively. Antidiabetic, anticholinesterase, and antioxidant activities of flower-fruit, root, aerial parts methanol extracts were evaluated. Apiole (35.0%), myristicine (72.2%), and myristicine (15.1%) were found as major compounds of fruit-flower mixture, root, aerial part essential oils, respectively. Hesperidin was found the highest amount in aerial part and flower-fruit extracts with 8904.2621 ng/mL and 11558.3634 ng/mL values, respectively. Fruit-flower extract showed the highest activity against alpha-glucosidase (24%). Root extract demonstrating the highest activity (18%) against AChE enzyme. Flowers-fruits mixture methanol extract had a higher % inhibition value on ABTS(+) and DPPH center dot. Flowers-fruits mixture methanol extract was rich in total phenol, total tannin, and protein content. All the extracts were determined as genetoxically safe according to the results of Ames/Salmonella, Escherichia coli WP2 and Allium cepa assays.
Self-Powered High-Performance UV-Vis Hybrid Photovoltaic Photodetector Based on Epilobium Angustifolium L. (Onagraceae)
(Elsevier Science SA, 2024) Yildirim, Fatma; Karakaya, Songuel; Yuca, Hafize; Incekara, Uemit; Aydogan, Sakir
Water-soluble Epilobium angustifolium (EA) extract was successfully coated on n -type Si single crystal by spin coating method to obtain EA/n-Si heterojunction device. UV-vis absorption and SEM analysis of the EA film were performed and the optical band gap was calculated as 2.71 eV. Electro-optical measurements of the fabricated device were performed and was found to give very good photoresponse in the UV-vis-IR regions. According to the experimental results, the EA/n-Si heterojunction showed not only high-performance photodetector properties but also self-driven properties under visible light as well as under UV and IR lights. At 150 mW/cm2 visible light, the device demonstrated excellent photovoltaic properties with Voc and Isc values of 0.40 V and 4.65 A, respectively. Under IR light, the responsivity, specific detectivity and NPDR reached 0.65 A/W and 1.41 x 1012 Jones, 4.23 x 108 W-1 respectively. Finally, a high-performance organic/inorganic photodetector in the broadband range has been successfully fabricated.