WoS İndeksli Yayınlar Koleksiyonu

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Citation - WoS: 5
Citation - Scopus: 4
3-Aminobenzamide Multifunctional Nanoparticles Enhances Anticancer Activity of Low-Dose Cisplatin Chemotherapy in Lung Adenocarcinoma
(Elsevier, 2024) Kaci, Fatma Necmiye; Daglioglu, Cenk
Chemotherapy is one of the main treatment methods for cancer patients, but its effectiveness is limited by drug resistance. Combining a chemotherapeutic agent with targeted molecular therapy may improve the curative effect of the chemotherapeutic agent. In this study, we investigate the efficacy of combining a 3-Aminobenzamide (3AB)-linked multifunctional platform with low-dose cisplatin chemotherapy aiming to modulate poly [ADP-ribose] polymerase 1 (PARP1) function in DNA repair to increase cytotoxic activity of the platinum-based cisplatin. The structure of the synthesized nanoplatforms was characterized by several physicochemical techniques, including dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and an in vitro pH-dependent release study. Cellular uptake experiments demonstrated preferentially targeted delivery of nanoparticles in lung carcinoma A549 cells, whereas the cellular uptake capacity was minimal in normal lung BEAS-2B cells. On the other hand, cytotoxicity experiments showed a reduction of cancer cell viability compared to free formulations. Furthermore, the combination treatment was examined by detecting the loss of mitochondrial membrane potential and the apoptotic cell population, confirming the treatment's functional involvement in apoptosis. Soft agar colony formation and cell invasion tests were also performed to detect the cancer cell's tumorigenic potential, confirming the synergistic effect of this combination in the reduction of tumorigenicity. Moreover, we analyzed the expression profiles of three candidate genes, which play important roles in cancer initiation, promotion and progression. Cell biology experiments indicated that this novel combination treatment possesses significant synergy between 3AB and low-dose cisplatin and is promising for development as an antitumor treatment for lung cancer.
Citation - WoS: 22
Citation - Scopus: 25
Accessibility of Vaccination Centers in COVID-19 Outbreak Control: A GIS-Based Multi-Criteria Decision Making Approach
(MDPI, 2021) Alemdar, Kadir Diler; Kaya, Omer; Codur, Muhammed Yasin; Campisi, Tiziana; Tesoriere, Giovanni
The most important protective measure in the pandemic process is a vaccine. The logistics and administration of the vaccine are as important as its production. The increasing diffusion of electronic devices containing geo-referenced information generates a large production of spatial data that are essential for risk management and impact mitigation, especially in the case of disasters and pandemics. Given that vaccines will be administered to the majority of people, it is inevitable to establish vaccination centres outside hospitals. Site selection of vaccination centres is a major challenge for the health sector in metropolitan cities due to the dense population and high number of daily cases. A poor site selection process can cause many problems for the health sector, workforce, health workers, and patients. To overcome this, a three-step solution approach is proposed: (i) determining eight criteria using from the experience of the advisory committee, (ii) calculating criterion weights using Analytic Hierarchy Process (AHP), and performing spatial analysis of criteria using Geographic Information System (GIS), (iii) assigning potential vaccination centres by obtaining a suitability map and determining service areas. A case study is performed for Bagcilar, Istanbul district, using the proposed methodology. The results show that the suitable areas are grouped in three different areas of the district. The proposed methodology provides an opportunity to execute a scientific and strategic vaccination programme and to create a map of suitable vaccination centres for the countries.
Citation - WoS: 13
Citation - Scopus: 17
Accurate Estimation of T Year Extreme Wind Speeds by Considering Different Model Selection Criterions and Different Parameter Estimation Methods
(Pergamon-Elsevier Science Ltd, 2018) Tosunoglu, Fatih
Accurate estimation of extreme wind speeds for different return periods is necessary to avoid extensive costs or large damages. To achieve this aim, the probability distribution of the wind speed data should be well defined and its parameters should be more precisely estimated. In this study, the commonly used probability distributions, including Gamma, Generalized Extreme Value, Logistic, Lognormal, Normal and Weibull, are fitted to annual maximum wind speed data in Turkey. Parameters of the fitted distributions are estimated using method of moments (MOM), method of maximum likelihood (MLM) and method of probability weighted moments (PWMs). Based on various model selection criterions (Akaike Information Criterion, Bayesian Information criterion, Anderson-Darling, Cramer-von-Mises, and Kolmogorov-Smirnov tests), the Generalized Extreme Value and Logistic, which provided the best fit for 40% and 30% of the series, respectively, were mostly found to be the most suitable distributions. Additionally, the Lognormal, Normal and Gamma distributions showed the best fit for 15%, 10% and 5% of the series, respectively. Moreover, the MLM and PWMs provided better parameter estimations for 57% and 30% the best fitted distributions, respectively. Furthermore, wind speed quantiles with the standard errors in various return periods were estimated using the best fitted distributions. (C) 2018 Elsevier Ltd. All rights reserved.
Citation - WoS: 7
Citation - Scopus: 7
The Acute Effects of Hip Thrust and Glute Bridge Exercises with Different Loads on Sprint Performance and Horizontal Force-Velocity Profile in Adolescent Soccer Players: A Post-Activation Performance Enhancement Approach
(Wiley, 2025) Cabuk, Salih; Ince, Izzet
This study examines the acute effects of post-activation performance enhancement (PAPE) with different loads (84% and 60% 1-RM) and exercises (hip thrust; HT and glute bridge; GB) on sprint performance (SP) and horizontal force-velocity (HF-V) profile components in adolescent male soccer players. The participants were randomly assigned to three groups: hip thrust group (HTG; n = 13), glute bridge group (GBG; n = 13), and control group (CG; n = 14). Sprint tests at distances of 10, 20, and 30 m were conducted pre-PAPE and post-PAPE protocols with a 7 min rest period. HTG and GBG executed HT and GB exercises at 84% and 60% of their 1-RM loads. Hedge's g was computed to assess within-group (pre-PAPE vs. post-PAPE) comparisons (Within-ES) and between-group (post-PAPE protocols) comparisons (Between-ES). PAPE protocols at 84% and 60% 1-RM loads demonstrated moderate effects on F0rel, Pmaxrel, FVslope, and DRF and small effects on V0, RFmax, and S20m in both HTG and GBG. Conversely, the CG exhibited trivial effects across parameters. Compared to the HTG 84% 1-RM protocol, the GBG 84% 1-RM protocol showed small effects on V0 and S10m. The HTG 60% 1-RM protocol had a small effect on RFmax compared to both GBG 84% and 60% 1-RM protocols. Both HTG and GBG 84% and 60% 1-RM protocols demonstrated small effects on S30m compared to the CG. These findings suggest that GB exercises may offer a viable alternative to HT exercises for eliciting PAPE effects, particularly in enhancing SP and related mechanics in adolescent soccer players.
Citation - WoS: 1
Citation - Scopus: 1
Acute Effects of Nordic Hamstring Exercise on Hamstring Stiffness: A Randomised Controlled Trial
(MDPI, 2025) Yagiz, Gokhan; Monleon, Cristina; Akaras, Esedullah; Adanir, Sena; Liebana, Encarnacion
Background: This study aimed to examine the immediate effects of the Nordic Hamstring Exercise (NHE) on the stiffness of the biceps femoris (BF) and semitendinosus (ST) muscles. Methods: This parallel-group randomised controlled trial followed CONSORT 2025 guidelines. Twenty-four physically active adults (16 females, 8 males) were randomly assigned to an NHE group (n = 12) or a control group (n = 12) using 1:1 gender-stratified randomisation. The NHE group performed 3 sets of 10 repetitions of the NHE, while the control group remained inactive. Muscle stiffness of the BF and ST was assessed pre- and post-intervention using the MyotonPro device. Results: No significant overall changes in hamstring stiffness were observed within or between groups (p > 0.05). Within the NHE group, the ST tended to increase in stiffness (11.25 N/m, p = 0.057), while the BF showed a small, non-significant reduction (-12.00 N/m, p = 0.696). The difference in changes between BF and ST was significant (p = 0.039). Independent of group allocation, males demonstrated significantly higher baseline stiffness than females for BF (258.13 vs. 195.81 N/m, p < 0.001) and for ST (247.88 vs. 174.00 N/m, p = 0.003). Regression analysis showed that only height predicted the change in ST stiffness after NHE (R = 0.625, R-2 = 0.39, p = 0.030). Conclusions: A single NHE session did not alter overall hamstring stiffness but produced opposite, muscle-specific effects. More research with larger, uniform samples is needed to confirm these findings.
Citation - WoS: 107
Citation - Scopus: 114
Additive Manufacturing of Multiple Layered Materials (Ti6Al4V/316L) and Improving Their Tribological Properties with Glow Discharge Surface Modification
(Pergamon-Elsevier Science Ltd, 2021) Tekdir, H.; Yetim, A. F.
Selective Laser Melting (SLM), which is a kind of laser powder bed fusion additive manufacturing technology, is commonly used in the manufacturing of AISI 316L stainless steel components. This study aims to enhance the mechanical and tribological properties of 316L manufactured by using SLM and plasma oxidation treatment in a glow discharge atmosphere. For that reason, Ti6Al4V layers were formed on 316L stainless steel samples by selective laser melting. Samples with a duplex structure (316L substrate and Ti6Al4V layer) were oxidized at 650 degrees C and 750 degrees C for 1 h and 4 h in the plasma atmosphere. The characterization of the formed Ti6Al4V and oxide layers is determined by the Vickers micro-hardness tester, scanning electric microscope, 3D profilometer, Energy dispersive X-ray spectrometer, and X-ray diffractometer. Wear tests were performed against Al2O3 balls under a load of 10 N, dry sliding ambient air conditions by a pin-on-disk tribometer. It was observed that the hardness and wear resistance of Ti6Al4V layered and plasma-oxidized samples were better than the uncoated 316L samples due to the formation of titanium oxide phases and diffusion zone depth. The best wear resistance is obtained in the sample with the highest hardness value.
Adherence to the Mediterranean Diet in Adults: The Role of Environmental and Sustainable Food Literacy
(BMC, 2025) Ozata-Uyar, Gizem; Aslan, Serkan; Camli, Ayse; Arslan, Merve; Bozkurt, Osman; Kocaadam-Bozkurt, Betul
AimThis study aimed to evaluate the relationship between environmental literacy, sustainable food literacy, and adherence to the Mediterranean diet (MD) in adults.MethodData were collected via a web-based questionnaire created using Google Forms between April and August 2024 in Erzurum, Turkey. A total of 394 adults participated through snowball sampling. The questionnaire included sections on demographic information, anthropometric measurements, the Environmental Literacy Scale for Adults (ELSA), the Sustainable Food Literacy Scale (SFLS), and the Mediterranean Diet Adherence Screener (MEDAS).Results38.6% of the participants were found to adhere to the Mediterranean Diet (MD). Married participants were more likely to have adhered to the MD than single ones (odds ratio [OR]:0.41, p = 0.006). Adherence to the MD was associated with higher education duration (OR = 1.05, p = 0.011), a higher SFLS total score (OR = 1.01, p = 0.025), and a higher ELSA score (OR = 1.04, p = 0.004).ConclusionThe MD is a sustainable dietary model that enhances health and is environmentally friendly. For this reason, it may be possible to direct society towards healthier and less environmentally damaging food choices through training to increase individuals' sustainable literacy and environmental literacy levels.
Citation - WoS: 62
Citation - Scopus: 70
The Advent of Indium Selenide: Synthesis, Electronic Properties, Ambient Stability and Applications
(MDPI AG, 2017) Boukhvalov, Danil W.; Gurbulak, Bekir; Duman, Songul; Wang, Lin; Politano, Antonio; Caputi, Lorenzo S.; Cupolillo, Anna
Among the various two-dimensional semiconductors, indium selenide has recently triggered the interest of scientific community, due to its band gap matching the visible region of the electromagnetic spectrum, with subsequent potential applications in optoelectronics and especially in photodetection. In this feature article, we discuss the main issues in the synthesis, the ambient stability and the application capabilities of this novel class of two-dimensional semiconductors, by evidencing open challenges and pitfalls. In particular, we evidence how the growth of single crystals with reduced amount of Se vacancies is crucial in the road map for the exploitation of indium selenide in technology through ambient-stable nanodevices with outstanding values of both mobility of charge carriers and ON/OFF ratio. The surface chemical reactivity of the InSe surface, as well as applications in the fields of broadband photodetection, flexible electronics and solar energy conversion are also discussed.
Citation - Scopus: 1
Aerobic Capacity and Respiratory Indices of Junior Cross-Country Skiers and Biathletes during Incremental Exercise Testing
(Nature Portfolio, 2024) Tortu, Erkan; Ouergui, Ibrahim; Deliceoglu, Gokhan; Keles, Ali; Ulupinar, Suleyman; Ozbay, Serhat; Ardigo, Luca Paolo
The present study compared the isocapnic buffering phase (ICB), hypocapnic hyperventilation phase, ventilatory threshold (VT), respiratory compensation point (RCP), and maximum oxygen uptake (VO2max) among biathlon and cross-country ski athletes during an incremental exercise test. 37 male and 33 female Turkish National Team athletes volunteered to participate in the research. Body fat percentage, lean mass, and fat mass values of athletes were measured using the bioelectrical impedance analysis method, and oxygen consumption (VO2) was measured with a portable cardiopulmonary exercise test system with a ramp protocol on the treadmill. In VT, RCP, and VO2max phases, male athletes had higher VO2 and speed values than female athletes (p 0.05). Additionally, XC skiers and males had higher absolute (Abs) VO2 and mass-normalized (Rel) VO2 values than biathletes and females in exhaustion times and ICBs (p 0.05). In addition, XC skiers and males had higher absolute (Abs) VO(2 )and relative (Rel) VO2 values than biathletes and females in exhaustion times and ICBs (p 0.05). These results indicate significant differences in physiological profiles between male and female athletes and between XC skiers and biathletes.
Citation - WoS: 1
Citation - Scopus: 1
Aerobic Exercise in Cold Weather May Affect Metabolic Diseases and Bone-Cartilage Formation by Increasing CTRP-3 Levels
(Wiley, 2024) Sebin, Saime Ozbek; Sebin, Engin; Gencoglu, Cebrail; Ozbay, Serhat; Ulupinar, Suleyman; Altinkaynak, Konca
Aerobic exercise is recommended by clinicians in the prevention and treatment of metabolic diseases. The aim of this study is to investigate the effect of aerobic exercise in cold weather on CTRP-3 levels and its potential implications for metabolic diseases. Twenty-seven healthy young individuals (age = 22.1 +/- 1.7 years, BMI = 22.2 +/- 1.3, and n = 27; 13 female and 14 male) voluntarily participated in this study. Participants performed 40 min aerobic running exercise at 0, 12, and 20 degrees C environmental temperatures. Our study demonstrates that 40 min of aerobic exercise at temperatures of 0 and 12 degrees C significantly increased CTRP-3 levels in athletes, while no significant change was observed at 24 degrees C. The main findings indicated significant differences between pre-and post-exercise CTRP-3 values for 0 degrees C (p = 0.001) and 12 degrees C (p = 0.005) environmental temperature, whereas no significant difference was found at 24 degrees C (p = 0.148). Additionally, two-way ANOVA revealed that both the temperature (0, 12, and 24 degrees C) and exercise (pre- and post-) affect serum CTRP-3 levels (p = 0.023). CTRP-3 elevation from baseline to post-exercise in the 0 degrees C, 12 degrees C, and 24 degrees C were +23.4%, +10.6%, and +8.1%, respectively. These findings suggest that engaging in aerobic exercise in cold weather conditions may serve as an effective intervention against metabolic disorders, including diabetes and obesity. The significant increases in CTRP-3 levels following aerobic exercise in cold weather conditions justify the need for further, more extensive studies to assess their potential impact on metabolic diseases, as well as cartilage and bone formation. Athletes' serum CTRP-3 levels in 40 min aerobic exercise at 0, 12, and 24 degrees C were evaluated by comparing them with their baselines and healthy controls' values. The significant increase in CTRP-3 levels of 0 and 120C of aerobic exercise suggests that it may influence metabolic diseases and bone-cartilage production.
Citation - WoS: 21
Citation - Scopus: 19
Alpha-B Expression in Human Laryngeal Squamous Cell Carcinoma Tissues
(Wiley, 2015) Yilmaz, Mehmet; Karatas, Omer Faruk; Yuceturk, Betul; Dag, Huseyin; Yener, Murat; Ozen, Mustafa
BackgroundLaryngeal squamous cell carcinoma (SCC), being an aggressive malignancy, is one of the most commonly diagnosed malignant types of head and neck SCC worldwide. The recent studies suggested that B-crystallin might play an important role in tumorigenesis. The purpose of this study was to investigate the B-crystallin expression level in metastatic and nonmetastatic laryngeal SCC tissues and to determine its prognostic significance. MethodsAlpha-B-crystallin expression status in metastatic, nonmetastatic laryngeal SCC, and normal tissue samples was investigated by quantitative real-time polymerase chain reaction (qRT-PCR). ResultsWe demonstrated that the expression of B-crystallin was significantly upregulated in laryngeal SCC tumor tissue samples in comparison with the corresponding normal tissues (p<.001), although no significant association has been found between B-crystallin expression and either the metastatic potential or the T classification of the specimens. ConclusionAlthough expression of B-crystallin is not statistically correlated with neck metastases, we demonstrated that B-crystallin is significantly overexpressed in laryngeal cancer. (c) 2014 Wiley Periodicals, Inc. Head Neck 37: 1344-1348, 2015
Citation - WoS: 2
Citation - Scopus: 2
Amelino-Camelia Dsr Effects on Landau Levels of Dirac Pairs with Non-Minimal Coupling
(Springer, 2025) Guvendi, Abdullah; Mustafa, Omar
We present an analytical study of a fermion-antifermion (ff\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f\overline{f}$$\end{document}) system governed by a two-body Dirac equation (TBDE) in (2+1)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$(2+1)$$\end{document}-dimensional Minkowski spacetime, incorporating Dirac oscillator (DO) interactions and a uniform magnetic field. We work within Amelino-Camelia's framework, capturing leading-order Planck-scale effects while preserving the TBDE's first-order structure. Separation of center-of-mass and relative coordinates reduces the problem to a Whittaker-type radial equation, yielding a closed-form energy spectrum. DSR induces uniform energy shifts that grow with radial excitation but preserve mass symmetry between particle and antiparticle. A critical magnetic field is identified, at which Planck-scale effects vanish and the spectrum collapses to the rest mass threshold, indicating suppressed spatial resolution. These findings provide a consistent platform for probing Planckian signatures in relativistic bound states and affirm the robustness of spectral symmetries under DSR.
Citation - WoS: 7
Citation - Scopus: 10
The Ameliorative Effect of Cetraria Islandica Against Diabetes-Induced Genetic and Oxidative Damage in Human Blood
(Taylor & Francis Ltd, 2013) Colak, Suat; Geyikoglu, Fatime; Turkez, Hasan; Bakir, Tulay Ozhan; Aslan, Ali
Context: The aqueous extracts of Cetraria islandica (L.) Ach. (Parmeliaceae) is traditionally used in many countries against a number of conditions, including inflammatory conditions. Objective: The present study aimed to assess, for the first time, the effectiveness of C. islandica in cultured primary blood cells of Type 1 diabetes subjects. Materials and methods: Diabetic and control blood samples were treated with or without aqueous lichen extract (5 and 10 mu g mL(-1)) for 48 h. The activity of antioxidant enzymes in erythrocytes and also malondialdehyde levels in plasma were determined to evaluate the oxidative status. DNA damages were analyzed by SCE, MN and comet assays in cultured human lymphocytes. Additionally, proliferation index (PI) was evaluated in peripheral blood lymphocytes. Results: There were significant increases in observed total DNA damage (comet assay) (240.2%) and SCE (168.8%), but not in MN frequencies of cultures with diabetes as compared (p>0.05) to controls. Whereas, the significant reductions of total DNA damage (69.2 and 65.3%) and SCE frequencies (17.7 and 12.3%) were determined when the 5 and 10 mg mL(-1) lichen extract was added to the cell culture medium, respectively. However, lichen extract did not completely inhibit the induction of SCEs in lymphocytes of patients with diabetes. C. islandica extract was also useful on PI rates. Discussion: In conclusion, the antioxidant role of C. islandica in alleviating diabetes-induced genomic instability and for increasing cell viability was firstly indicated in the present study.
Citation - WoS: 12
Citation - Scopus: 14
Ameliorative Effects by Hexagonal Boron Nitride Nanoparticles Against Beta Amyloid Induced Neurotoxicity
(MDPI, 2022) Aydin, Nursah; Turkez, Hasan; Tozlu, Ozlem Ozdemir; Arslan, Mehmet Enes; Yavuz, Mehmet; Sonmez, Erdal; Mardinoglu, Adil
Alzheimer's disease (AD) is considered as the most common neurodegenerative disease. Extracellular amyloid beta (A beta) deposition is a hallmark of AD. The options based on degradation and clearance of A beta are preferred as promising therapeutic strategies for AD. Interestingly, recent findings indicate that boron nanoparticles not only act as a carrier but also play key roles in mediating biological effects. In the present study, the aim was to investigate the effects of different concentrations (0-500 mg/L) of hexagonal boron nitride nanoparticles (hBN-NPs) against neurotoxicity by beta amyloid (A beta(1-42)) in differentiated human SH-SY5Y neuroblastoma cell cultures for the first time. The synthesized hBN-NPs were characterized by X-ray diffraction (XRD) measurements, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). A beta(1-42)-induced neurotoxicity and therapeutic potential by hBN-NPs were assessed on differentiated SH-SY5Y cells using MTT and LDH release assays. Levels of total antioxidant capacity (TAC) and total oxidant status (TOS), expression levels of genes associated with AD and cellular morphologies were examined. The exposure to A beta(1-42) significantly decreased the rates of viable cells which was accompanied by elevated TOS level. A beta(1-42) induced both apoptotic and necrotic cell death. A beta exposure led to significant increases in expression levels of APOE, BACE 1, EGFR, NCTSN and TNF-alpha genes and significant decreases in expression levels of ADAM 10, APH1A, BDNF, PSEN1 and PSENEN genes (p < 0.05). All the A beta(1-42)-induced neurotoxic insults were inhibited by the applications with hBN-NPs. hBN-NPs also suppressed the remarkable elevation in the signal for A beta following exposure to A beta(1-42) for 48 h. Our results indicated that hBN-NPs could significantly prevent the neurotoxic damages by A beta. Thus, hBN-NPs could be a novel and promising anti-AD agent for effective drug development, bio-nano imaging or drug delivery strategies.
Citation - WoS: 5
Citation - Scopus: 4
Ameliorative Effects of SL on Tolerance to Salt Stress on Pepper (Capsicum Annuum L.) Plants
(Elsevier France-Éditions Scientifiques Médicales Elsevier, 2025) Yuce, Merve; Aydin, Murat; Turan, Metin; Ilhan, Emre; Ekinci, Melek; Agar, Guleray; Yildirim, Ertan
Salinity is one of the most important problems that threaten agricultural production, especially in arid and semiarid areas. Strigolactones (SLs) are important in providing tolerance to various abiotic stresses in plants. The study was carried out in a hydroponic system to determine the effects of external GR24 (were applied as a foliar spray; 0, 10, and 20 mu M) applications at different doses on plant growth and some physiological, biochemical, and gene expression in two pepper genotype (Yalova and Maras,) grown under salt stress (0 and 100 mM NaCl). Plants were harvested and measured 10 days after the NaCl treatments. At the end of the research, it was determined that salt stress negatively affected plant growth in both genotype. Still, SL applications positively affected plant development both under normal and salt stress. While salt stress increased the amount of hydrogen peroxide (H2O2) and malondialdehyde (MDA), SL application caused a decrease in these parameters. Salt stress negatively affected the amount of chlorophyll and photosynthetic properties in both genotype, whereas SL applications mitigated this negative effect. SL applications caused a significant increase in antioxidant enzyme activities under both normal and salt stress conditions. SL content, which decreased with salt stress, increased with exogenous SL application. The content of other plant nutrients except sodium (Na) and chloride (Cl) decreased significantly in pepper seedlings grown under salt stress. External SL applications increased the uptake of these nutrients, especially under salt stress. In addition, the expression levels of CIPK3, CBL2, CCD7, DMAX2, PsbA, PsbB, PsbP1, TIP1;2, TIP5;1, SOS1, SOS2 and HKT2;2 genes were investigated in this study. It was observed that the expression levels of CCD7, DMAX2, SOS1, SOS2, and HKT2;2 genes increased with salinity stress, especially in the Maras, genotype, while SL applications decreased these expression levels. In the study, it was determined that especially exogenous 20 mu M SL application could significantly reduce the negative effects of salt stress in pepper.
Citation - WoS: 1
Ameliorative Effects of Strigolactone on Tolerance to Lead Stress on Lettuce (Lactuca Sativa L.) Plants
(Nature Portfolio, 2025) Ucar, Sumeyra; Yuce, Merve; Yigider, Esma; Aydin, Murat; Turan, Metin; Ekinci, Melek; Yildirim, Ertan
Soil contamination by heavy metals, particularly lead (Pb), which is considered the second most toxic metal, poses serious risks to plants and humans due to its accumulation from various anthropogenic activities. Strigolactones (SLs) are a novel class of terpenoid lactones that play a vital role in regulating plant growth and development, particularly under stress conditions. This study aimed to investigate the impact of exogenous SL applications on plant growth and various physiological, biochemical, and molecular parameters in lettuce subjected to Pb stress. Pb stress harmed plant growth, whereas SL treatments improved growth parameters under both control and Pb stress conditions. While Pb stress increased the electrical conductivity (EC), malondialdehyde (MDA) and hydrogen peroxide (H2O2) content, SL applications caused a decrease in these parameters. Pb stress negatively affected chlorophyll content, whereas SL applications reduced negative effect. Pb caused an increase in superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) ascorbate peroxidase (APX), glutathione reductase (GR), glutathione s-transferase (GST) activities and Glucose-6-Phosphate Dehydrogenase (G6PD), 6-Phosphogluconate Dehydrogenase (6GPD). SL treatments significantly increased the activity of antioxidant enzymes in both control and Pb stress conditions. However, Pb stressed plants had lower nitrate reductase activity (NRA) than the control plants while SL treatments increased NRA compared to the non-treatments. Pb stress significantly reduced the uptake of essential nutrients in lettuce seedlings, whereas exogenous SL applications improved nutrient accumulation, particularly under Pb-stressed conditions. Additionally, mRNA expression profiles of nine stress-related genes in different tissues of lettuce were determined. Only Pb stress significantly decreased the expression of genes, particularly LsCCD8 and LsD14, in both tissues. The combined Pb and SL treatment significantly increased the expression of LsMAX2 in both tissues. These results suggest that exogenous SL applications can be an effective strategy to mitigate Pb-induced stress in lettuce by enhancing plant tolerance at physiological, biochemical, and molecular levels.
Citation - WoS: 10
Citation - Scopus: 11
Amplification of Coupled Hot-Dry Extremes Over Eastern Monsoon China
(American Geophysical Union, 2023) Zhang, Xinxin; Gu, Xihui; Slater, Louise J.; Dembele, Moctar; Tosunoglu, Fatih; Guan, Yansong; Tang, Xiongpeng
High air temperatures and low atmospheric humidity can result in severe disasters such as flash droughts in regions characterized by high humidity (monsoon regions). However, it remains unclear whether responses of hot extremes to warming temperature are amplified on dry days as well as the response of dry extremes on hot days. Here, taking eastern monsoon China (EMC) as a typical monsoon region, we find a faster increase in air temperature on drier summer days, and a faster decrease in atmospheric humidity on hotter days, indicating "hotter days get drier" and "drier days get hotter" (i.e., coupling hotter and drier extremes), especially in southern EMC. The southern EMC is also a hotspot where the coupling hot-dry extremes has become significantly stronger during the past six decades. The stronger hot-dry coupling in southern EMC is associated with anomalies in large-scale circulations, such as reduced total cloud cover, abnormal anticyclones in the upper atmosphere, intense descending motion, and strong moisture divergence over this region. Land-atmosphere feedback enhance the hot-dry coupling in southern EMC by increasing land surface dryness (seen as a decrease in the evaporation fraction). The decreasing evaporation fraction is associated with drying surface soil moisture, controlled by decreases in pre-summer 1-m soil moisture and summer-mean precipitation. Given hot extremes are projected to increase and atmospheric humidity is predicted to decrease in the future, it is very likely that increasing hot-dry days and associated disasters will be witnessed in monsoon regions, which should be mitigated against by adopting adaptive measures. High air temperatures (i.e., hot extremes) and low atmospheric humidity (i.e., dry extremes) are regarded as important metrics affecting human society and the environment in monsoon regions, including food production and natural disasters. Our results show that over eastern monsoon China (EMC), positive responses of hot extremes to warming temperature are magnified on dry days, at the same time, negative responses of dry extremes to warming temperature are enhanced on hot days. In other words, the warming rates of hot extremes per 1 degrees C warming are fastest on dries days, meanwhile, the drying rates of dry extremes per 1 degrees C warming are fastest on hottest days, especially in southern EMC. The southern EMC is also a hotspot where more hot or dry days have become hot-dry days (i.e., stronger coupling of hot and dry extremes) during the past six decades. This stronger coupling of hot and dry extremes can be explained by anomalous large-scale circulations and land-atmosphere feedbacks in southern EMC. Our findings suggest that the positive coupling of hotter and drier extremes should be taken into consideration, and adaptive measures are required to mitigate adverse effects of hot and dry extremes. Positive (negative) responses of hot (dry) extremes to warming temperature are amplified on dry (hot) days over eastern monsoon ChinaCoupling of hot and dry extremes has strengthened in past six decades in southern EMCCoupling of hotter and drier extremes can be explained by anomalies of large-scale circulations and land-atmosphere feedbacks
Citation - WoS: 31
Citation - Scopus: 31
Analysis of Factors Affecting Alcohol and Tobacco Concurrent Use by Bivariate Probit Model in Turkey
(Springer Heidelberg, 2021) Alkan, Omer; Abar, Hayri; Gencer, Ozge
Alcohol and tobacco use are risky factors that are associated with one another. High alcohol and tobacco use are significant public health problems with social and economic costs and one of the leading causes of preventable death and disease. The aim of this study was to determine the sociodemographic and economic factors on alcohol and tobacco concurrent use. In this study, a bivariate probit model was employed to determine the factors affecting alcohol and tobacco concurrent use among individuals aged 15 and above who were living in Turkey. The data used in this study was obtained from the Turkey Health Survey conducted in 2010, 2012, 2014, and 2016 by the Turkish Statistical Institute. The data were gathered from a total of 77,327 individuals. Empirical findings suggest that factors affecting alcohol and tobacco use were simultaneous. Also, the results revealed that several key variables such as age, gender, educational status, marital status, household monthly income level, and survey year were significant determinants of alcohol and tobacco concurrent use. Psychosocial support is significant for only tobacco use. In the last decade, a number of restrictions aimed to combat alcohol and tobacco use have been associated with reducing the usage habits of individuals. This is the first study that simultaneously compared both alcohol use and tobacco use using a Turkish sample.
Analysis of Thermal Energy Storage in Batch Processes Using Phase Change Materials
(Springer, 2025) Kaya, Nur Efsan; Ceviz, Mehmet Akif; Afshari, Faraz; Mandev, Emre; Koksal, Huseyin
Batch reactors are widely utilized in the chemical, pharmaceutical, and food industries due to their simplicity, ease of operation, and maintenance. However, efficient energy management remains a key challenge, especially for systems operating under intermittent conditions. While phase-change materials (PCMs) offer potential for improving energy efficiency by storing and reusing waste heat, integrating heat storage within reactors can compromise their volume and design. This study introduces a novel approach by designing and experimentally testing a PCM heat battery positioned outside the reactor to reduce energy consumption cost in batch processes. By focusing on peak load shifting, the PCM heat battery stores thermal energy during off-peak periods, reducing operational costs and enhancing energy efficiency. The results indicate that energy operating costs can be significantly reduced with a PCM heat battery. Specifically, utilizing the PCM battery under a three-time tariff allows for the efficient use of energy stored at night, reducing the energy cost per batch process by approximately 8%, from 1.72 TL ($0.041) to 1.59 TL ($0.037) for facilities starting operations at 08:00. Furthermore, the findings suggest potential applications in systems like solar energy and highlight the benefits of peak load shifting, offering a sustainable and cost-effective solution for energy management in batch processing.
Citation - WoS: 1
Citation - Scopus: 1
Anthracene-Pyridine Derivatives as Fluorescent Probes: The Role of Nitrogen Positioning in Bioimaging Performance
(Elsevier Science Sa, 2026) Aydemir, Murat; Haykir, Gulcin; Demir, Seda; Aydemir, Esra; Arslan, Elif; Selvitopi, Harun; Turksoy, Figen
The strategic design of small-molecule fluorescent probes is critical for advancing precision bioimaging in both cellular and microbiological contexts. In this study, we report a series of anthracene-pyridine derivatives-compounds 3a, 3b, and 3c-with nitrogen atoms positioned at the ortho, meta, and para positions, respectively, to investigate how atomic-level substitution patterns govern photophysical properties and imaging performance. Spectroscopic characterization revealed that the para-substituted compound 3c exhibits enhanced intramolecular charge transfer (ICT) character, leading to lower fluorescence quantum yield in polar biological environments due to increased non-radiative decay. In contrast, the meta-substituted derivative 3b maintains a more locally excited (LE)-like emission, producing intense blue fluorescence and demonstrating high selectivity for bacterial imaging, likely due to favourable interactions with nucleic acids or membranes. Ortho-substituted compound 3a also displayed appreciable fluorescence in mammalian cells, though with lower intensity and reduced bacterial uptake. Complementary molecular dynamics simulations revealed that nitrogen positioning influences molecular geometry, conformational stability, and interaction propensities with biological targets, thereby shaping the observed bioimaging performance. Collectively, these findings establish clear structure-property-function relationships, underscoring how fine-tuning nitrogen placement can optimize excited-state behaviour, cellular uptake, and emission output. These insights provide a valuable framework for the rational design of next-generation fluorophores tailored for multicolour and environment-sensitive imaging applications.

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