Comparison of Detailed Brain Volume Measurements in Schizophrenia with Healthy Individuals

Abstract

Aims: This study aims to provide insights into the preliminary and definitive diagnosis, treatment modalities, and elucidation of the underlying pathophysiological mechanisms of schizophrenia, alongside ongoing research efforts. Methods: This retrospective study examined a cohort of 31 patients (17 male, 14 female) diagnosed with schizophrenia according to the criteria specified in the Diagnostic and Statistical Manual of Mental Disorders (DSM V) at the psychiatry clinic of the university hospital. The healthy control group, comprising 31 individuals (17 male, 14 female), was selected from archived records at the same hospital, with sociodemographic characteristics matching those of the patient group. Highresolution T1-weighted MRI images of the individuals were analyzed using the VolBrain AssemblyNet program. Results: It has been observed that the volumes of various brain structures, including white matter (WM), gray matter (GM), subcortical GM, cortical GM, WM+GM, IC, total cerebrum, right cerebrum, left cerebrum, cerebrum WM, cerebrum GM, are significantly reduced (p<0.05) in patients diagnosed with schizophrenia compared to healthy controls. Additionally, volumes of cerebellar WM, GM, vermis, brainstem, accumbens, hippocampus, thalamus, ventral diencephalon, amygdala, and basal forebrain were found to be decreased in schizophrenia patients compared to healthy controls. Conversely, volumes of the pallidum, caudate, putamen, inferior lateral ventricle, lateral ventricle, third ventricle, fourth ventricle, and CSF were observed to be increased. Conclusion: These findings underscore the widespread nature of neuroanatomical alterations in schizophrenia and highlight the importance of understanding these changes for elucidating the disorder’s pathophysiology and developing targeted therapeutic interventions. Further research is warranted to explore the interplay of genetic, developmental, and environmental factors in schizophrenia.