Karacaer, C.Güzel Erdoğan, D.G.Tanyeli, A.Baylan, H.Eraslan, E.Güler, M.C.Çomaklı, S.2026-03-262026-03-2620231128-36022284-072910.26355/eurrev_202304_319112-s2.0-85152976498https://doi.org/10.26355/eurrev_202304_31911https://hdl.handle.net/20.500.14901/3513OBJECTIVE: As an antioxidant and anti-inflammatory agent, Hesperidin was investigated to prove whether it prevents damage to the kidney and lung tissues of rats undergoing renal ischemia-reperfusion injury. MATERIALS AND METHODS: Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal ischemia reperfusion), Groups 3 and 4 as pretreatment groups (50 HES, 100 HES). RESULTS: According to our results, Hesperidin pretreatment improved the biochemical and histopathological parameters in kidney and lung tissues of rats with ischemia-reperfusion injury. Besides, a 100 mg/kg dose of Hesperidin was found to be more beneficial to the rats than 50 mg/kg. CONCLUSIONS: The study suggests that Hesperidin is protective against renal and lung tissues of rats that underwent ischemia-reperfusion injury. © 2023 Verduci Editore s.r.l. All rights reserved.eninfo:eu-repo/semantics/closedAccessHesperidinInjuryLungRemote OrganRenal Ischemia-ReperfusionArticle