Akincioglu, AkinAkbaba, YusufKose, Leyla PolatAkyuz, Leyla DemirkolGoksu, Sueleyman2026-03-262026-03-2620230040-40201464-541610.1016/j.tet.2023.1332772-s2.0-85147304838https://doi.org/10.1016/j.tet.2023.133277https://hdl.handle.net/20.500.14901/3176Polat Köse, Leyla/0000-0001-5759-7889; Akıncıoğlu, Akın/0000-0002-6473-6338; Göksu, Süleyman/0000-0003-1280-3954We performed the racemic synthesis and asymmetric resolution of one 2-aminoindane and three 2-aminotertalins due to their crucial biological roles in the central nervous system (CNS). For this reason, desired (+/-)-2-aminoindane and (+/-)-2-aminotetralin derivatives were synthesized starting from appropriate reagents. While highly enantio pure (+)-39, (+)-40, and ( inverted exclamation )-40 were obtained from the reaction of racemic amines with (R)-O-acetylmandeloyl chloride followed by crystallization, hydrolysis with KOH and acidification with HCl, (S)-42 and (-)-43 were synthesized via the reaction of racemic amines with (S)-mandelic acid and hydrolysis.(c) 2023 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessDopaminergic Compounds2-Aminotetralin2-AminoindaneAsymmetric ResolutionMandelic AcidO-Acetylmandeloyl ChlorideArticle