Karakaya, S.Ozdemir, O.O.İncekara, U.Türkez, H.Sytar, O.Aksakal, O.2026-03-262026-03-2620231015-391810.33483/jfpau.12664212-s2.0-85173640757https://doi.org/10.33483/jfpau.1266421https://search.trdizin.gov.tr/en/yayin/detay/1197143/salvia-verticillata-l-achillea-biebersteinii-afan-tragopogon-aureus-boiss-ve-cephalaria-procera-fisch-and-ave-lallnin-hemostatik-performanslarinin-in-vitro-degerlendirilmesihttps://hdl.handle.net/20.500.14901/3557Objective: Hemostasis is an inherent function and natural process to prevent or stop bleeding. Nowadays great efforts are being made to develop novel, economical and high-performance products to control bleeding. In this study, we aimed to assess the in vitro hemostatic effects of four several plant species used in folk medicine for different purposes including Salvia verticillata, Achillea biebersteinii, Tragopogon aureus, and Cephalaria procera. Material and Method: The extracts with different solvent nature were prepared and their hemostatic efficacy were determined using optical aggregometry. Result and Discussion: The present results clearly revealed that the extracts of S. verticillata showed the highest efficacy on platelet aggregation in presence of adenosine-diphosphate (ADP) (80.77%), collagen (80.78%), and arachidonic acid (AA) (73.71%) when compared to other plant extracts. Again, the most effective platelet aggregation (47.27%) was determined after the application C. procera within the presence of epinephrine (EPI). Moreover, we first executed that ethyl acetate extracts led to the highest percentages of platelet aggregation in the fact of APD, collagen, AA and EPI. In a conclusion, our findings suggested that the tested medicinal plants in particular S. verticillata and C. procera could be novel and natural sources of effective hemostatic agents. © 2023 University of Ankara. All rights reserved.trinfo:eu-repo/semantics/openAccessAchillea BiebersteiniiCephalaria ProceraHemostasisSalvia VerticillataTragopogon AureusArticle