Ozen, M.Karatas, O.F.2026-03-262026-03-2620139781118300312978111830039810.1002/9781118300312.ch182-s2.0-85018853526https://doi.org/10.1002/9781118300312.ch18https://hdl.handle.net/20.500.14901/3767Prostate cancer (PCa) is one of the most frequent new cancer diagnoses and cancer-associated deaths among men worldwide. MicroRNAs (miRNAs) have been shown to participate in prostate carcinogenesis, and their aberrant expression has been detected in PCa cell lines, xenografts, and clinical samples. In this chapter, we have reviewed and summarized the most current evidence, including our own work, that implicates miRNA involvement in human prostate cancerogenesis. The possible roles of miRNAs in tumorigenesis through both the genetic and epigenetic changes occurring during cancer initiation, development, invasion, or metastasis are summarized. We believe that this chapter will help investigators not only working in prostate cancer but also studying the miRNAs in other diseases to delineate the functions of miRNAs implicated in human PCa development, progression, and therapy. © 2014 by John Wiley & Sons, Inc. All rights reserved.eninfo:eu-repo/semantics/closedAccessmiRNAOncomirProstate CancerSmall RNAsTSmiRTumor SuppressorBook Part