Bilek, FurkanErcan, ZubeydeDeniz, GulnihalOzgul, SinemDemir, Caner Feyzi2026-03-262026-03-2620240165-57281872-842110.1016/j.jneuroim.2024.5784342-s2.0-85201719589https://doi.org/10.1016/j.jneuroim.2024.578434https://hdl.handle.net/20.500.14901/3446Deniz, Gülnihal/0000-0002-5944-8841;The study aimed to evaluate the effect of high-intensity intermittent exercise (HIIE) on serum levels of MMP-9 and CHI3L1 in multiple sclerosis. Study group received HIIE twice a week for 12 weeks, while control group received no treatment. In intra-group comparison, study group showed a significant increase in MMP-9 and CHI3L1 levels, while control group showed no significant difference. In intergroup comparison, a significant difference was found only in CHI3L1 levels after treatment. The increase in MMP-9 and CH3L-1 concentrations in study group suggests that these biomarkers may play a role in regulating specific skeletal muscle adaptations due to HIIE.eninfo:eu-repo/semantics/closedAccessMultiple SclerosisMMP-9High-Intensity Interval ExerciseBiomarkerArticle