Yuca, HafizeSefali, AbdurrahmanAydin, BilgeKaradayi, MehmetGulsahin, YusufYazici, AysenurGuvenalp, Zuhal2026-03-262026-03-2620251478-64191478-642710.1080/14786419.2024.23726612-s2.0-85197876348https://doi.org/10.1080/14786419.2024.2372661https://hdl.handle.net/20.500.14901/3312Coban, Furkan/0000-0003-2815-8988; Karadayi, Mehmet/0000-0002-2473-0409;Essential oil content of and phenolic compounds flower-fruit, root, and aerial parts of Heracleum pastinacifolium subsp. incanum were analysed by GC/MS and LC/MS methods, respectively. Antidiabetic, anticholinesterase, and antioxidant activities of flower-fruit, root, aerial parts methanol extracts were evaluated. Apiole (35.0%), myristicine (72.2%), and myristicine (15.1%) were found as major compounds of fruit-flower mixture, root, aerial part essential oils, respectively. Hesperidin was found the highest amount in aerial part and flower-fruit extracts with 8904.2621 ng/mL and 11558.3634 ng/mL values, respectively. Fruit-flower extract showed the highest activity against alpha-glucosidase (24%). Root extract demonstrating the highest activity (18%) against AChE enzyme. Flowers-fruits mixture methanol extract had a higher % inhibition value on ABTS(+) and DPPH center dot. Flowers-fruits mixture methanol extract was rich in total phenol, total tannin, and protein content. All the extracts were determined as genetoxically safe according to the results of Ames/Salmonella, Escherichia coli WP2 and Allium cepa assays.eninfo:eu-repo/semantics/closedAccessAlzheimer'sDiabetesGenotoxicHeracleum Pastinacifolium Subsp. IncanumHesperidinMyristicineArticle