Buzdagli, YusufEyipinar, Cemre DidemKaci, Fatma NecmiyeTekin, Aslihan2026-03-262026-03-2620230960-31231369-161910.1080/09603123.2022.20938412-s2.0-85133247445https://doi.org/10.1080/09603123.2022.2093841https://hdl.handle.net/20.500.14901/1861Kaci, Fatma Necmiye/0000-0003-3745-8173; Tekin, Aslıhan/0000-0002-1760-5378; Buzdağli, Yusuf/0000-0003-1809-5194; Eyipınar, Cemre Didem/0000-0002-9778-2074Hesperidin is a prominent flavanone found in citrus fruits that has a broad range of biological effects, including anti-inflammatory and antioxidant capabilities. The study's objective was to evaluate the effects of hesperidin supplementation on anti-inflammatory and antioxidant parameters such as MDA, TAC, GSH, SOD, and CAT; CRP, TNF-alpha, IL-6, and IL-4 levels respectively, by analyzing human intervention trials. Google Scholar, PubMed, grey literature databases, and the ClinicalTrials website were scanned to identify eligible studies. For the meta-analysis, eighteen studies were chosen. Hesperidin supplementation had significant lowering effect on not only CRP, IL-6, and IL-4 levels but also MDA level (Meta-regression analysis revealed a non-significant direct relationship between hesperidin dosage and chance in CRP, IL-6, and MDA levels. As a result, it can be said that hesperidin supplementation contributes to the inflammatory and antioxidant response, but this contribution is independent of dosage.eninfo:eu-repo/semantics/closedAccessCitrus FlavanoneFlavonoidsInflammatory MarkersAntioxidant ResponseMeta-RegressionArticle