TR-Dizin İndeksli Yayınlar

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14901/697

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Comparison of Detailed Brain Volume Measurements in Schizophrenia with Healthy Individuals
(2024) Karakurt, Nurgül; Acer, Niyazi; Ozcan, Halil; Deniz, Gülnihal
Aims: This study aims to provide insights into the preliminary and definitive diagnosis, treatment modalities, and elucidation of the underlying pathophysiological mechanisms of schizophrenia, alongside ongoing research efforts. Methods: This retrospective study examined a cohort of 31 patients (17 male, 14 female) diagnosed with schizophrenia according to the criteria specified in the Diagnostic and Statistical Manual of Mental Disorders (DSM V) at the psychiatry clinic of the university hospital. The healthy control group, comprising 31 individuals (17 male, 14 female), was selected from archived records at the same hospital, with sociodemographic characteristics matching those of the patient group. Highresolution T1-weighted MRI images of the individuals were analyzed using the VolBrain AssemblyNet program. Results: It has been observed that the volumes of various brain structures, including white matter (WM), gray matter (GM), subcortical GM, cortical GM, WM+GM, IC, total cerebrum, right cerebrum, left cerebrum, cerebrum WM, cerebrum GM, are significantly reduced (p<0.05) in patients diagnosed with schizophrenia compared to healthy controls. Additionally, volumes of cerebellar WM, GM, vermis, brainstem, accumbens, hippocampus, thalamus, ventral diencephalon, amygdala, and basal forebrain were found to be decreased in schizophrenia patients compared to healthy controls. Conversely, volumes of the pallidum, caudate, putamen, inferior lateral ventricle, lateral ventricle, third ventricle, fourth ventricle, and CSF were observed to be increased. Conclusion: These findings underscore the widespread nature of neuroanatomical alterations in schizophrenia and highlight the importance of understanding these changes for elucidating the disorder’s pathophysiology and developing targeted therapeutic interventions. Further research is warranted to explore the interplay of genetic, developmental, and environmental factors in schizophrenia.
Metamfetamin Kullanım Bozukluğunda Beyin Hacmi Ölçümlerinin Volbrain Yöntemi Kullanılarak Sağlıklı Bireylerle Karşılaştırılması
(2023) Karakurt, Nurgül; Acer, Niyazi; Ozcan, Halil; Deniz, Gülnihal
Amaç: Bu çalışmanın amacı, metamfetamin kullanım bozukluğu (MKB) olan bireylerde beyin yapılarını incelemek ve metamfetaminin bu yapılar üzerindeki olası etkilerini anlamaktır. Gereç ve Yöntem: Çalışmada 21 MKB ve 21 sağlıklı kontrol retrospektif olarak değerlendirildi. VolBrain segmentasyon yöntemi kullanıldı. Bulgular: Substantia grisea (SG), kortikal SG serebrum total ve SG hacimleri sağlıklı kontrol grubuna kıyasla daha az ve anlamlı bulunmuştur (p<0,01). Accumbens, pars basalis telencephali, lobus caudatus, globus pallidus, putamen ve lobus parietalis hacimleri MKB’de artmıştır (p<0,01). Amygdala, hippocampus, ventral diensefalon, lobus frontalis, gyrus orbitalis posterior, gyrus precentralis, lobus temporalis, calcarine cortex, gyrus occipitalis medium, gyrus occipitalis superior, lobus limbicus hacimleri MKB’de sağlıklı kontrollere kıyasla anlamlı derecede küçüktü. Sonuç: Bu çalışma, MKB’nin beyin yapıları üzerindeki etkilerini daha iyi anlamamıza yardımcı oldu. Ayrıca, MKB tedavisi ve önlenmesi için etkili stratejiler geliştirmek için önemli bilgiler sağlamıştır.

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