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Citation - WoS: 126
Citation - Scopus: 125
Carbonic Anhydrase Inhibitory Properties of Novel Benzylsulfamides Using Molecular Modeling and Experimental Studies
(Academic Press Inc Elsevier Science, 2014) Goksu, Suleyman; Naderi, Ali; Akbaba, Yusuf; Kalin, Pinar; Akincioglu, Akin; Gulcin, Ilhami; Salmas, Ramin Ekhteiari
In this study, a series of sulfamoyl carbamates and sulfamide derivatives were synthesized. Six commercially available benzyl amines and BnOH were reacted with chlorosulfonyl isocyanate (CSI) to give sulfamoyl carbamates. Pd-C catalyzed hydrogenolysis reactions of carbamates afforded sulfamides. The inhibition effects of novel benzylsulfamides on the carbonic anhydrase I, and II isoenzymes (CA I, and CA II) purified from fresh human blood red cells were determined by Sepharose-4B-L-Tyrosine-sulfanilamide affinity chromatography. In vitro studies were shown that all of novel synthesized benzylsulfamide analogs inhibited, concentration dependently, both hCA isoenzyme activities. The novel benzylsulfamide compounds investigated here exhibited nanomolar inhibition constants against the two isoenzymes. K-i values were in the range of 28.48 +/- 0.01-837.09 +/- 0.19 nM and 112.01 +/- 0.01-268.01 +/- 0.22 nM for hCAI and hCA II isoenzymes, respectively. Molecular modeling approaches were also applied for studied compounds. (C) 2014 Elsevier Inc. All rights reserved.
Co-Occurrence of the Nucleopolyhedrovirus and Bidensovirus in Silkworm, Bombyx Mori L.: Evidence from Kashmir and Molecular Comparison of Indian Bidensovirus Isolates
(Academic Press Inc Elsevier Science, 2026) Mumtaz, Shabnum; Gani, Mudasir; Eroglu, Gozde B.; Rather, Tariq Rasool; Wani, Arif Hussain; Mohi-ud-Din, Sajad; Gupta, Rakesh Kumar
The mulberry silkworm, Bombyx mori L. (Lepidoptera: Bombycidae), is an economically important insect domesticated for silk production in India and other countries, whereas the Bombyx mori nucleopolyhedrovirus (BmNPV) and Bombyx mori bidensovirus (BmBDV) are the two most serious viral pathogens infecting the domestic silkworms. In this study, the frequency of co-occurrence of BmNPV and BmBDV in silkworm larvae from sericulture practicing regions of North, Central, and South Kashmir was investigated. The prevalence of grasserie disease (%) and extent of cocoon crop loss varied significantly between the different regions. On the basis of PCR analyses, the mean co-occurrence (%) of BmNPV and BmBDV infection was 94%, 92.7% and 98% in the samples from North, Central and South Kashmir, respectively. The BmBDV isolates from Mysore, Andhra Pradesh, Tamil Nadu, Kashmir, Dehradun, Ghumarwin and Jammu grouped together and are most closely related to other BmBDV isolates on the basis of gene sequencing and phylogenetic analyses of the VD-1 gene fragments. The BmBDV-S1 isolate had the lowest LD50 and ST50 values revealing that it was more virulent to B. mori larvae as compared to BmBDV-N1 and BmBDV-C1 isolates. Overall, the results revealed that the BmNPV and BmBDV coexist in the silkworm larvae and highlight the need for greater research into the interaction of these viruses in Bombyx mori.
Citation - WoS: 1
Citation - Scopus: 1
Colemanite and Biological Disruptions: Behavioral, Neurological, and Physiological Findings
(Academic Press Inc Elsevier Science, 2025) Turkez, Hasan; Tozlu, Ozlem Ozdemir; Saracoglu, Melik; Yildiz, Edanur; Baba, Cem; Bayram, Cemil; Cadirci, Kenan
Colemanite (COL), a boron-containing mineral, has shown potential therapeutic applications, particularly in the fields of drug delivery and bone health. However, despite its promising bioactive properties, there is a lack of comprehensive toxicological data on its safety, especially regarding its potential medical use. Previous studies have primarily focused on its industrial applications, with limited investigation into its biological effects. This gap in knowledge prompted the current study, which aimed to investigate the subacute toxicity of colemanite in rats using behavioral, hematological, biochemical, genotoxic, and histopathological analyses. Over a 7-day period, rats were treated with doses of 10, 30, and 300 mg/kg. Behavioral assessments, including locomotor activity and elevated plus maze tests, indicated enhanced exploratory behaviors, indicating heightened curiosity or activity and no alterations in motor coordination or anxiety-like behaviors. Hematological findings revealed dose-dependent reductions in hematocrit, hemoglobin, and red blood cell counts, while biochemical analyses showed elevated aspartate aminotransferase, lactate dehydrogenase, and cholesterol levels at higher doses, suggesting hepatotoxicity and lipid metabolism disruption. Genotoxicity analysis demonstrated increased micronucleus formation at 30 and 300 mg/kg, indicative of chromosomal instability possibly linked to oxidative stress. Histopathological evaluations revealed mild hepatocyte degeneration and hyperemia in the liver and brain tissues at the highest dose. Importantly, no significant toxic effects were observed at the 10 mg/kg dose. These findings highlight the dose-dependent toxicity of colemanite, with low doses exhibiting a favorable safety profile. This study underscores the need for dose optimization and further research to elucidate the molecular mechanisms underlying colemanite's toxicological effects, including its impact on various organs over both short-term and long-term exposures. Additionally, future studies should focus on assessing the human relevance of these effects to ensure its safe and effective therapeutic application.
Citation - WoS: 3
Citation - Scopus: 3
Damped Photonic Modes in Helical Graphene
(Academic Press Inc Elsevier Science, 2025) Guvendi, Abdullah; Mustafa, Omar; Karabulut, Abdulkerim
We analyze the behavior of spin-1 vector bosons in helical spacetime, focusing on photonic modes in helical graphene structures. We model the helical graphene surface as a smooth, continuous, and distortion-free manifold, effectively adopting the continuum approximation. By solving the fully covariant vector boson equation, we derive exact solutions that describe the quantum states of photons in a curved helical background, revealing their energy spectra, mode profiles, and decay dynamics. We find that the decay times of damped photonic modes range from 10-16 to 10-13 s as the helical pitch (a) varies from 103 nanometers to 1 nanometer, indicating that the structure efficiently absorbs all photonic modes. Additionally, the probability density functions exhibit time dependence, complementing their spatial variation. These findings provide a foundation for the design of ultrafast graphene photodetectors, graphene photodevices for high-speed optical communications, advanced photonic devices, and quantum materials based on helical graphene for various nanophotonic applications.
Citation - WoS: 3
Citation - Scopus: 5
Fusion of Multifocus Images by Lattice Structures
(Academic Press Inc Elsevier Science, 2016) Kaplan, N. H.; Erer, I.; Ersoy, O.
Image fusion methods based on multiscale transform (MST) suffer from high computational load due to the use of fast Fourier transforms (ffts) in the lowpass and highpass filtering steps. Lifting wavelet scheme which is based on second generation wavelets has been proposed as a solution to this issue. Lifting Wavelet Transform (LWT) is composed of split, prediction and update operations all implemented in the spatial domain using multiplications and additions, thus computation time is highly reduced. Since image fusion performance benefits from undecimated transform, it has later been extended to Stationary Lifting Wavelet Transform (SLWT). In this paper, we propose to use the lattice filter for the MST analysis step. Lattice filter is composed of analysis and synthesis parts where simultaneous lowpass and highpass operations are performed in spatial domain with the help of additions/multiplications and delay operations, in a recursive structure which increases robustness to noise. Since the original filter is designed for the undecimated case, we have developed undecimated lattice structures, and applied them to the fusion of multifocus images. Fusion results and evaluation metrics show that the proposed method has better performance especially with noisy images while having similar computational load with LSWT based fusion method. (C) 2016 Elsevier Inc. All rights reserved.
Gene Expression and Characterization of an Antimicrobial Peptide from Medicago Sativa "sazova" Cultivar
(Academic Press Inc Elsevier Science, 2025) Turgut, Busra Albayrak; Ortucu, Serkan; Bezirganoglu, Ismail
In recent years, the discovery of new antimicrobial agents has become necessary because of the increase in antibiotic resistance, the development of herbicides and fungicides resistance. Among the antimicrobial agents, antimicrobial peptides (AMPs) stand out due to their stable structure. In this study, the aim was to identify a thermostable AMP from the seeds of M. sativa "Sazova" cultivar and to analyze gene expression during germination. Antimicrobial tests were performed for the seed peptides after heat treatment (85 degrees C for 10 min), revealing antimicrobial effects against S. aureus, E. coli, and C. albicans. Subsequently, the peptide band corresponding to the inhibition zone was identified as M. sativa Defensin 2.1 (MsDef2.1, MW: 5.2048 kDa). The gene expression analysis of MsDef2.1 in Sazova cultivar showed that the gene was expressed different plant organs, and the expression was decreased over time. As a result of the gene analysis of two cultivars (Sazova and LegenDairy) it was found that there are 5 base differences in the coding sequence and 3 amino acid differences between the sequences of MsDef2.1 isoforms from the LegenDairy and Sazova cultivars. The physiochemical properties, secondary, and tertiary structure of the Sazova Defensin 2.1 were predicted by using bioinformatic tools. Due to the amino acid substitutions in gamma-core structures, the antimicrobial activity of the isoforms is expected to differ from each other. These findings demonstrated that the defensin MsDef2.1 can differ in M. sativa cultivars in respect of the gene and amino acid sequences and has a potential for future applications.
Citation - WoS: 5
Citation - Scopus: 5
Impact of Long-Term Deltamethrin Exposure on Alzheimer's-Related Neurodegeneration in Rats
(Academic Press Inc Elsevier Science, 2025) Altun, Serdar; Ozdemir, Selcuk; Arslan, Harun; Kiliclioglu, Metin; Yaprak, Esra; Bolat, Smail; Aydin, Seyma
In recent years, epidemiological studies have emerged indicating a potential association between chronic exposure to pesticides and the development of chronic neurodegenerative nervous system diseases such as Alzheimer's disease. In this study, we aimed to investigate the potential role of long-term nonfatal exposure to Deltamethrin in spreading this disease. To this end, a range of aspects of brain damage were discussed in rats administered deltamethrin in oral doses of 0.65 mg/kg b.w. and 1.3 mg/kg b.w. for 30 days. The activation of beta-amyloid, the primary component of plaques characteristic of Alzheimer's disease, and the NG2, a type 1 transmembrane protein, was assessed by immunohistochemistry and western blot methods in rat brain. In addition, the expression level of the APP, GFAP, NfL, TNF-alpha, CXCL9, CCL5, and IL-1 alpha genes in deltamethrin-exposed brain tissue was measured using qRT-PCR. In addition, levels of pTau181 and Abeta42 were measured with ELISA. A strong positive immunohistochemical reaction for beta-amyloid was detected in the deltamethrin-exposed brain tissues. A decrease in NG2 immunofluorescence positivity was found in the application groups compared to the control group. It was demonstrated that deltamethrin exposure significantly up-regulated the expressions of APP, GFAP, NfL, TNF-alpha, CXCL9, CCL5, and IL-1 alpha genes, also significantly higher the levels of pTau181 and Abeta42 (pg/ml) in rat brain tissues. This study provides scientific evidence that exposure to chronic doses of deltamethrin may play a positive role in the development of diseases such as Alzheimer's. Future studies should investigate similar projects and expand knowledge on the topic.
Citation - WoS: 6
Citation - Scopus: 6
Investigating Quantum Criticality Through Charged Scalar Fields Near the BTZ Black Hole Horizon
(Academic Press Inc Elsevier Science, 2025) Guvendi, Abdullah; Mustafa, Omar
We examine a charged scalar field with a position-dependent mass m(rho)=m0+S(rho), where S(rho) represents a Lorentz scalar potential, near a BTZ black hole in the presence of an external magnetic field. By deriving the Klein-Gordon equation for this setup, we explore two scenarios: (i) a mass-modified scalar field with m(rho)=m0-a/rho (an exactly solvable case), and (ii) a scenario involving both mass modification and an external magnetic field (conditionally exactly solvable). We identify quantum critical points (QCPs) associated with the coupling constant a. In the first scenario, for massless charged scalar fields, critical points occur at a=n+1/2 for all radial quantum numbers n >= 0 and magnetic quantum numbers |m|>= 0. In the second scenario, these critical points shift to a=n+3/2 for n >= 0 and |m|>0, with the case m=0 excluded. For massive scalar fields, QCPs emerge at a=(n+1/2)/2, leading to non-propagating fields at zero frequency. At these QCPs, the field frequencies drop to zero, marking transitions from stable oscillatory modes to non-propagating states. Below the critical points, the system exhibits instability, characterized by negative imaginary frequencies that suggest rapid decay and high dissipation. Above the critical points, the modes stabilize and propagate, indicating a transition to a superconducting-like phase, where dissipation vanishes and stable excitations dominate.
Citation - WoS: 16
Citation - Scopus: 17
Low Complexity Clutter Removal in Gpr Images Via Lattice Filters
(Academic Press Inc Elsevier Science, 2020) Kumlu, Deniz; Erer, Isin; Kaplan, Nur Huseyin
A low complexity ground-penetrating radar (GPR) clutter removal method based on lattice filter (LF) decomposition is proposed. The GPR image is decomposed into several levels by LF where each level contains approximation and directional subbands. Due to its horizontal structure, the clutter is contained in a horizontal subband, while vertical and diagonal subbands represent the target information. Although the proposed approach seems similar to the classical undecimated wavelet decomposition, the whole process is accomplished in the spatial domain by simple mathematical operations and time delays, thus it has less complexity compared to the wavelet transform which needs the use of fast Fourier transform operations. Moreover, due to the recursive nature of the LFs, the proposed method is more robust to noise. It presents a better detection performance as indicated by the quantitative results. Our method is also compared with the conventional subspace-based methods for both simulated and real datasets, and visual and quantitative results validate the superiority of our proposed method. (C) 2020 Elsevier Inc. All rights reserved.
Citation - WoS: 3
Citation - Scopus: 3
The Monotony of the Q-Bessel Functions
(Academic Press Inc Elsevier Science, 2025) Ozkan, Yucel; Korkmaz, Semra; Deniz, Erhan
In this paper, we prove a monotonicity property for the normalized Jackson and Hahn-Exton q-Bessel functions using the method of subordination factor sequences. Additionally, in the special case of q -> 1, we obtain the result of Cot & icirc;rl & aacute; and Sz & aacute;sz (2024) [8]. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Citation - WoS: 8
Citation - Scopus: 10
New Color Channel Driven Physical Lighting Model for Low-Light Image Enhancement
(Academic Press Inc Elsevier Science, 2025) Kucuk, S.; Severoglu, N.; Demir, Y.; Kaplan, N. H.
Outdoor imaging systems, affected by low-light conditions, generally produce low-quality images with poor visibility. Low-quality images can directly influence high-level tasks such as surveillance and autonomous navigation systems. Enhancing the images captured under inadequate lighting conditions aims to generate higher visual quality in these images. However, current low-light enhancement methods may result in color unnaturalness, information loss, and strange artifacts. We propose a new color channel-driven physical lighting model (NCC-PLM) to respond to these issues to improve image quality. More concretely, we first apply a gamma correction to the input image according to its darkness degree, which is determined by its average intensity value. Then, we introduce a new color channel prior to estimate the environmental light (EL) and light scattering attenuation rate (LSAR). Finally, the enhanced image is obtained through the estimations and physical lighting model. Experimental results on various datasets demonstrate the proposed method's effectiveness and superiority over the compared methods both visually and qualitatively. Specifically, we enhance the visual quality of low- light images by revealing intricate details and maintaining color consistency, leading to a natural appearance.
Citation - WoS: 11
Citation - Scopus: 10
Pixel-Wise Low-Light Image Enhancement Based on Metropolis Theorem
(Academic Press Inc Elsevier Science, 2024) Demir, Y.; Kaplan, N. H.; Kucuk, S.; Severoglu, N.
Images taken in low-light conditions frequently encounter visibility problems, such as severe noise, reduced brightness, and low contrast. This paper introduces an approach to enhance low-light images using the Metropolis Theorem (MT). The method begins by applying a global gamma correction to the input image, followed by transforming the globally corrected image into the HSV (Hue, Saturation, Value - V) domain. To achieve multi-scale decomposition, an application of the MT is proposed, resulting in approximation and detail sub-images of the V component. Subsequently, local gamma correction is employed on both the final approximation and detail images to enhance local contrast. The refined approximation and detail images are then combined to reconstruct the refined V component. The reconstructed image is obtained by weighting each band of the image with the refined V component. Experimental results demonstrate that the proposed method outperforms state-of-the-art methods, providing improved visual quality and more natural colors.
Citation - WoS: 32
Citation - Scopus: 40
Real-World Image Dehazing with Improved Joint Enhancement and Exposure Fusion
(Academic Press Inc Elsevier Science, 2023) Kaplan, Nur Huseyin
In this work, a single image dehazing method that improves the haze removal capacity of the Joint Contrast Enhancement and Exposure Fusion (CEEF) method with Smoothing-Sharpening Image Filter (SSIF) is presented. In this method, the hazy image is first sharpened with SSIF to obtain a sharper image. In this way, the difference between haze and objects is amplified. Then, the AHE procedure in CEEF is replaced by CLAHE to obtain an enhanced CEEF. The enhanced CEEF is applied to the filtering result to obtain the final dehazed image. Observations demonstrate that the proposed method obtains enhanced results while reducing the amount of haze. The visual and quantitative comparisons between the proposed method and state-of-the-art dehazing methods show that the proposed method has better dehazing performance and has a 50% improvement in terms of the FADE metric compared to the closest result.
The Relationship Between Self-Efficacy, Illness-Related Fear, and Intolerance of Uncertainty in Patients Who Have Epilepsy in Eastern Türkiye: A Path Analysis
(Academic Press Inc Elsevier Science, 2025) Erden, Yasemin; Turan, Gulcan Bahcecioglu; Karakurt, Nurgul; Bakir, Ercan
Background: The effects of psychological factors such as self-efficacy, illness-related fear, and intolerance of uncertainty on illness management and quality of life of patients who have epilepsy have important roles in understanding the health behaviors of individuals. Aim: The present study was conducted to examine the relationship between self-efficacy, illness-related fear, and intolerance of uncertainty in patients who have epilepsy and to investigate the mediating role of illness-related fear in the relationship between self-efficacy and intolerance of uncertainty. Method: This cross-sectional and correlational study had a descriptive design and was conducted with 150 epilepsy patients who met the inclusion criteria and applied to the neurology clinic of a university hospital. The study population comprised epilepsy patients who applied to the Neurology Clinic of a university hospital in eastern Turkiye between May 2024 and August 2024. The data were collected by using the Personal Information Form, Epilepsy Self-Efficacy Scale, Illness-Related Fear Scale, and Mishel Uncertainty in Illness Scale - Community Form. The Structural Equation Modeling and Bootstrapping Methods were used to analyze the study data. The study was reported following the STROBE Recommendations. Results: Based on the findings, self-efficacy was found to negatively affect intolerance of uncertainty about the illness (b = -0.384, 95 % CI [-0.462 to -0.306], p < 0.01) and illness-related fear (b = -0.449, 95 % CI [-0.544 to -0.344], p < 0.01). Also, illness-related fear was found to positively affect intolerance of uncertainty (b = 0.688, 95 % CI [0.586 to 0.789], p < 0.01). The indirect effect of self-efficacy on intolerance of uncertainty through illness-related fear (b = -0.309, 95 % CI [-0.444 to -0.210], p < 0.01) was found to be negative and significant and the total effect (b = -0.693, 95 % CI [-0.789 to -0.597], p < 0.01) was also negative and significant. Self-efficacy explained 34 % of the illness-related fear and 59 % of the total intolerance of uncertainty in the model. The estimated effects were calculated with 5000 repeated operations and were evaluated to be significant because the indirect effects did not include zero in the 95 % Confidence Interval. Conclusion: The results of the present study showed that self-efficacy has a direct negative impact on intolerance of uncertainty in patients who have epilepsy and that fear related to the illness plays mediating roles in this effect.
Citation - WoS: 3
Citation - Scopus: 5
Scale Aware Remote Sensing Image Enhancement Using Rolling Guidance
(Academic Press Inc Elsevier Science, 2021) Kaplan, N. H.; Erer, I
Enhancement of remotely sensed images is a challenging problem, since the enhanced image has to have an improved contrast and edge information while preserving the original radiance values as much as possible. In this paper, a scale aware enhancement method based on rolling guidance is proposed for remotely sensed images. For each scale, a guidance image is defined and the approximation image is provided by an iterative joint filtering of the approximation and guidance images. Then the extracted details are amplified through an adaptive scheme and added to the final level approximation layer to provide the resulting enhanced image. A comparative study between the proposed methods with classical edge preserving filters and traditional methods have been carried out by using several criteria. The proposed methods have an average of 12% improvement for contrast gain (CG) metric and 81% improvement for enhancement measurement (EME) metric compared to the closest comparison method.
Citation - WoS: 12
Citation - Scopus: 13
Substituted Phenethylamine-Based 8-Lactam Derivatives: Antimicrobial, Anticancer, and 8-Lactamase Inhibitory Properties
(Academic Press Inc Elsevier Science, 2022) Yildirim, Merve; Ozgeris, Bunyamin; Gormez, Arzu
In this study, a series of novel 8-lactam derivatives were synthesized with yields ranging from 41 % to 91 %, and their antimicrobial activities were investigated against bacterial and fungal isolates that cause nosocomial in-fections. The results revealed that the novel 8-lactam derivatives, especially compound 19, showed antibacterial activities ranging from 0.98 to 250 mu g/mL. In contrast, the compounds showed no antifungal activity against fungal isolates. Following that, biochemical (Nitrocefin) investigation of compounds with antibacterial activity was carried out, as well as their effects on the 8-lactamase enzyme. According to the results, the compounds inhibited the 8-lactamase enzyme against bacterial isolates. Furthermore, the anticancer activity and toxicity profiles of 8-lactam derivatives were also studied against colorectal cancer (Caco-2), the most common type of cancer, and non-human dermal fibroblast cell line. The results revealed that compound 19 was shown the best anticancer activity and lowest toxicity profile among other compounds. Therefore, these compounds, especially compound 19, could be useful in the treatment of colorectal cancer and related nosocomial infections. Furthermore, the potential of being an antibiotic can be put forward by investigating the resistant mechanism and further pharmacological studies.
Citation - WoS: 2
Citation - Scopus: 2
Synthesis and Evaluation of Sulfonamide-Chalcone Hybrid Compounds as Inhibitors of Vegfr1/Vegfr2-Mediated Angiogenesis
(Academic Press Inc Elsevier Science, 2025) Barlak, Neslisah; Sanli, Fatma; Celik, Suleyman; Iskender, Burhan; Anil, Derya Aktas; Gambacorta, Nicola; Karatas, Omer Faruk
Cancer continues to be a major worldwide health concern, with angiogenesis playing a pivotal role in its progression and metastasis. The capacity of tumors to induce angiogenesis is crucial for their proliferation and metastasis, rendering it a significant target for treatment strategies. This study involved the synthesis of sulfonamide-chalcone hybrid compounds and the evaluation of their anti-angiogenic activity by the assessment of their effects on vascular endothelial growth factor receptors (VEGFR1/VEGFR2) in human umbilical vein endothelial cells (HUVECs). Among the synthesized compounds, 28 and 31 exhibited the most promising inhibitory effects similar to sorafenib as positive control, with IC50 values superior to 10 mu M. They dramatically diminished endothelial cell proliferation and tube formation without exhibiting significant cytotoxicity against healthy human cells. Molecular docking simulations validated their binding affinity to VEGFR1/VEGFR2 receptors, elucidating their molecular mechanisms. Moreover, compounds 28 and 31 exhibited significant antiangiogenic activity in both 2D and 3D angiogenesis assays, indicating their potential as novel anti-cancer agents. These findings underscore the therapeutic potential of these compounds in blocking angiogenesis and necessitate additional in vivo research to confirm their clinical relevance.
Synthesis and in Vitro/In Silico Evaluation of Novel Aroyl Thiourea Derivatives Based on Substituted Phenethylamine: Antibacterial, Antioxidant, and Anticancer Activities
(Academic Press Inc Elsevier Science, 2026) Yildirim, Merve; Ozgeris, Bunyamin; Gormez, Arzu
Thiourea derivatives possess a wide spectrum of biological activities and play a crucial role in drug design due to their anticancer, antimicrobial, antiviral, and enzyme inhibitory properties. In this study, seven novel substituted phenethylamine-based aroyl thiourea derivatives (23-29) with previously unreported structures were synthesized, and their biological activities were comprehensively evaluated. In the synthesis step, various substituted phenethylamines were reacted with 4-methoxyphenyl chloroformate in the presence of potassium thiocyanate, and the resulting compounds were characterized using FT-IR and NMR spectroscopic techniques. Antibacterial assays revealed that compounds 25, 26, and 28 exhibited strong antibacterial activity against multidrug-resistant pathogenic strains, with MIC values ranging from 6.25 to 100 mu M. Notably, compounds 25, 27, and 28 displayed the most potent efficacy with MIC values as low as 6.25 mu M. Antioxidant analyses performed using the CUPRAC and DPPH methods demonstrated that electron-donating groups (compound 27) enhanced reducing capacity, whereas electron-withdrawing groups (compound 28) limited this effect. In anticancer evaluations, compounds 27 and 28 exhibited significant antiproliferative activity against A549 cells with IC50 values of 124.4 mu M and 106.1 mu M, respectively, while displaying minimal cytotoxicity toward normal HDF-1 cells. In silico analyses indicated that all synthesized compounds complied with Lipinski's rule of five and possessed favorable bioavailability. Molecular docking studies further confirmed these findings, revealing strong binding affinities ranging from -5.3 to -9.2 kcal/mol. Specifically, compound 26 showed the highest binding potential with a score of -9.2 kcal/mol against the target protein (PDB ID: 5AA4). These findings suggest that the synthesized aroyl thiourea derivatives serve as promising multifunctional biological agent candidates.

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