Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan Β-Lactam Derivatives
| dc.contributor.author | Genc, Hayriye | |
| dc.contributor.author | Kalin, Ramazan | |
| dc.contributor.author | Koksal, Zeynep | |
| dc.contributor.author | Sadeghian, Nastaran | |
| dc.contributor.author | Kocyigit, Umit M. | |
| dc.contributor.author | Zengin, Mustafa | |
| dc.contributor.author | Ozdemir, Hasan | |
| dc.date.accessioned | 2026-03-26T14:48:47Z | |
| dc.date.available | 2026-03-26T14:48:47Z | |
| dc.date.issued | 2016 | |
| dc.description | Gulcin, Ilhami/0000-0001-5993-1668; Zengin, Mustafa/0000-0002-0243-1432; Sadeghian, Nastaran/0009-0004-2966-9231; Kocyigit, Umit Muhammet/0000-0001-8710-2912; Köksal, Zeynep/0000-0003-4800-9461; Genç Bilgiçli, Hayriye/0000-0001-6909-316X | en_US |
| dc.description.abstract | beta-Lactams are pharmacologically important compounds because of their various biological uses, including antibiotic and so on. beta-Lactams were synthesized from benzylidene-inden derivatives and acetoxyacetyl chloride. The inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and acetylcholinesterase (AChE). The results reveal that beta-lactams are inhibitors of hCA I, II and AChE. The Ki values of beta-lactams (2a-k) were 0.44-6.29 nM against hCA I, 0.93-8.34 nM against hCA II, and 0.25-1.13 nM against AChE. Our findings indicate that beta-lactams (2a-k) inhibit both carbonic anhydrases (CA) isoenzymes and AChE at low nanomolar concentrations. | en_US |
| dc.description.sponsorship | Sakarya University [BAPK-2012-02-04-031] | en_US |
| dc.description.sponsorship | We gratefully acknowledge the partial financial support for this research project from Sakarya University BAPK-2012-02-04-031. | en_US |
| dc.identifier.doi | 10.3390/ijms17101736 | |
| dc.identifier.issn | 1422-0067 | |
| dc.identifier.scopus | 2-s2.0-84992092066 | |
| dc.identifier.uri | https://doi.org/10.3390/ijms17101736 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14901/2181 | |
| dc.language.iso | en | en_US |
| dc.publisher | MDPI | en_US |
| dc.relation.ispartof | International Journal of Molecular Sciences | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Carbonic Anhydrase | en_US |
| dc.subject | Acetylcholinesterase | en_US |
| dc.subject | Beta-Lactam | en_US |
| dc.subject | 2-Azetidinone | en_US |
| dc.subject | Enzyme Inhibition | en_US |
| dc.subject | Enzyme Purification | en_US |
| dc.title | Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan Β-Lactam Derivatives | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Gulcin, Ilhami/0000-0001-5993-1668 | |
| gdc.author.id | Zengin, Mustafa/0000-0002-0243-1432 | |
| gdc.author.id | Sadeghian, Nastaran/0009-0004-2966-9231 | |
| gdc.author.id | Kocyigit, Umit Muhammet/0000-0001-8710-2912 | |
| gdc.author.id | Köksal, Zeynep/0000-0003-4800-9461 | |
| gdc.author.id | Genç Bilgiçli, Hayriye/0000-0001-6909-316X | |
| gdc.author.scopusid | 36863335700 | |
| gdc.author.scopusid | 55937509300 | |
| gdc.author.scopusid | 55981532600 | |
| gdc.author.scopusid | 57191624817 | |
| gdc.author.scopusid | 57189006957 | |
| gdc.author.scopusid | 8984510400 | |
| gdc.author.scopusid | 35509141500 | |
| gdc.author.wosid | Gulcin, Ilhami/F-1428-2014 | |
| gdc.author.wosid | Zengin, Mustafa/Htt-3124-2023 | |
| gdc.author.wosid | Kocyigit, Umit Muhammet/Hjh-9546-2023 | |
| gdc.author.wosid | Köksal, Zeynep/W-8066-2019 | |
| gdc.author.wosid | Genç Bilgiçli, Hayriye/U-4685-2017 | |
| gdc.description.department | Erzurum Technical University | en_US |
| gdc.description.departmenttemp | [Genc, Hayriye; Zengin, Mustafa] Sakarya Univ, Fac Arts & Sci, Dept Chem, TR-54050 Sakarya, Turkey; [Kalin, Ramazan] Erzurum Tech Univ, Dept Basic Sci, Fac Sci, TR-25700 Erzurum, Turkey; [Koksal, Zeynep] Istanbul Medeniyet Univ, Dept Chem, Fac Sci, TR-34730 Istanbul, Turkey; [Sadeghian, Nastaran; Gulcin, Ilhami] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey; [Kocyigit, Umit M.] Cumhuriyet Univ, Vocat Sch Hlth Serv, TR-58140 Sivas, Turkey; [Gulcin, Ilhami] King Saud Univ, Dept Zool, Coll Sci, Riyadh 11451, Saudi Arabia | en_US |
| gdc.description.issue | 10 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q2 | |
| gdc.description.volume | 17 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | Q1 | |
| gdc.identifier.wos | WOS:000387768300031 | |
| gdc.virtual.author | Kalın, Ramazan | |
| relation.isAuthorOfPublication | b64620fd-409c-4377-9ae9-0370820bb12d | |
| relation.isAuthorOfPublication.latestForDiscovery | b64620fd-409c-4377-9ae9-0370820bb12d |