Synthesis of Substituted Phenethylamine-Based Thioureas and Their Antimicrobial and Antioxidant Properties

Abstract

Thiourea-based scaffolds are increasingly used in medicinal chemistry owing to their tunable structural properties. This study demonstrates the first examples of phenethylamine-based thiourea derivatives and their antimicrobial and antioxidant activities. All compounds exhibited strong antibacterial activity against tested bacteria known to cause nosocomial infections, which have acquired resistance to many antibiotics, and also strong antioxidant properties. Therefore, they can be evaluated as possible antibacterial and antioxidant agents in the treatment of bacterial infections and many health problems related to aging.