Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins

Abstract

Background and Aims. In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays. Results. The obtained data revealed that tested compounds showed a variable degree of cytotoxic activity against the tested cell lines. 3-(5-methoxy-1,2,3,4-tetrahydronaphthalenl-y1)-1,1-dimethylurea (9) and 3-(6-methoxy-1,2,3,4-tetrahydronaphthalen-l-y1)-1, 1-dimethylurea (10) proved to be the most active cytotoxic members in this study. Conclusions. These two compounds could be considered as possible anticancer agents. (C) 2017 IMSS. Published by Elsevier Inc.